Potential Novel Risk Factor for Breast Cancer:Toxocara canisInfection Increases Tumor Size Due to Modulation of the Tumor Immune Microenvironment
Por:
Alejandra Ruiz-Manzano, Rocio, Isabel Palacios-Arreola, Margarita, Hernandez-Cervantes, Rosalia, Hugo Del Rio-Araiza, Victor, Elizabeth Nava-Castro, Karen, Ostoa-Saloma, Pedro, Munoz-Cruz, Samira, Morales-Montor, Jorge
Publicada:
29 may 2020
Resumen:
Worldwide, breast cancer is the most important type of cancer in women
with regard to incidence and prevalence. Several risk factors interact
to increase the probability of breast cancer development. Biological
environmental contaminants such as infectious agents play a significant
role in tumor development, and helminths have been recognized as cancer
enhancers or inducers due to their ability to regulate the host immune
response.Toxocara canisis a zoonotic and cosmopolite nematode with
immuno-regulatory abilities.T. canisinfection has been related to T
helper type-2 cell (Th2 or type 2) and regulatory responses. Type 2 and
regulatory immune responses may favor the development of comorbidities
that are usually controlled or eliminated through a type 1 response such
as cancer. The aim of this study was to determine whetherT.
canisinfection alters mammary tumor growth through modulation of the
immune response. Infected mice developed larger tumors. Tumor immune
cell milieu analysis revealed that infection reduced the proportions of
CD8(+)lymphocytes and increased the proportions of F4/80(+)macrophages
and CD19(+)B cells. These changes were accompanied by a type 2 local
response represented by increased amounts of IL-4 and VEGF and a
regulatory microenvironment associated with higher IL-10 levels. Thus,
this study demonstrates thatT. canisinfection enhances tumor development
and suggests that this is through modulation of the tumor immune
microenvironment.
Filiaciones:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Inmunol, Ciudad De Mexico, Mexico
Univ Nacl Autonoma Mexico, Ctr Ciencias Atmosfera, Dept Genotoxicol & Mutagenesis Ambiental, Ciudad De Mexico, Mexico
Univ Nacl Autonoma Mexico, Fac Med Vet & Zootecnia, Dept Parasitol, Lab Inmunol & Biol Mol Parasitos, Ciudad De Mexico, Mexico
Inst Mexicano Seguro Social, Unidad Invest Med Enfermedades Infecciosas & Para, Ciudad De Mexico, Mexico
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