Heptapeptide HP3 acts as a potent inhibitor of experimental imiquimod-induced murine psoriasis and impedes the trans-endothelial migration of mononuclear cells
Por:
Vazquez-Sanchez, Ernesto A., Mendoza-Figueroa, Jose S., Gutierrez-Gonzalez, Guadalupe, Zapi-Colin, Luis A., Torales-Cardena, Azael, Briseno-Lugo, Paola E., Diaz-toala, Ivan, Cancino-Diaz, Juan C., Perez-Tapia, Sonia M., Cancino-Diaz, Mario E., Gomez-Chavez, Fernando, Rodriguez-Martinez, Sandra
Publicada:
1 jul 2020
Resumen:
During the progression of psoriatic lesions, abundant cellular
infiltration of myeloid cells, such as macrophages and activated
dendritic cells, occurs in the skin and the infiltrating cells interact
with naive lymphoid cells to generate a T helper (Th)1 and Th17
environment. Therapies to treat psoriasis include phototherapy,
non-steroidal and steroidal drugs, as well as antibodies to block tumor
necrosis factor-alpha, interleukin (IL)-17-A and IL-12/IL-23, which all
focus on decreasing the proinflammatory hallmark of psoriasis. The
present study obtained the heptapeptide HP3 derived from phage display
technology that blocks mononuclear cell adhesion to endothelial cells
and inhibits trans-endothelial migrationin vitro. The activity of the
heptapeptide in a murine model of psoriasis was also assessed, which
indicated that early administration inhibited the development of
psoriatic lesions. Therefore, the results suggested that HP3 may serve
as a potential therapeutic target for psoriasis.
Filiaciones:
Vazquez-Sanchez, Ernesto A.:
Inst Politecn Nacl IPN, Escuela Nacl Ciencias Biol ENCB, Dept Immunol, Lab Innate Immunol, Rd Plan Ayala & Prolongac Carpio, Mexico City 11340, DF, Mexico
Escuela Nacl Med & Homeopatia ENMyH IPN, Dept Disciplinary Basic Format, Mexico City 07320, DF, Mexico
Mendoza-Figueroa, Jose S.:
Linkoping Univ, Dept Phys Chem & Biol, S-58183 Linkoping, Sweden
Gutierrez-Gonzalez, Guadalupe:
Inst Politecn Nacl IPN, Escuela Nacl Ciencias Biol ENCB, Dept Immunol, Lab Innate Immunol, Rd Plan Ayala & Prolongac Carpio, Mexico City 11340, DF, Mexico
Zapi-Colin, Luis A.:
Inst Politecn Nacl IPN, Escuela Nacl Ciencias Biol ENCB, Dept Immunol, Lab Innate Immunol, Rd Plan Ayala & Prolongac Carpio, Mexico City 11340, DF, Mexico
Torales-Cardena, Azael:
Escuela Nacl Med & Homeopatia ENMyH IPN, Dept Disciplinary Basic Format, Mexico City 07320, DF, Mexico
Briseno-Lugo, Paola E.:
Univ Nacl Autonoma Mexico, Fac Estudios Super Cuautitlan, Dept Biol Sci, Hlth Sci Sect, Mexico City 54740, DF, Mexico
Diaz-toala, Ivan:
Escuela Super Comp IPN, Dept Computat Syst Engn, Mexico City 07738, DF, Mexico
Cancino-Diaz, Juan C.:
ENCB IPN, Lab Immunomicrobiol, Dept Microbiol, Mexico City 11340, DF, Mexico
Perez-Tapia, Sonia M.:
ENCB IPN, Natl Lab Specialized Serv Res Dev & Innovat Pharm, Mexico City 11340, DF, Mexico
Cancino-Diaz, Mario E.:
Inst Politecn Nacl IPN, Escuela Nacl Ciencias Biol ENCB, Dept Immunol, Lab Innate Immunol, Rd Plan Ayala & Prolongac Carpio, Mexico City 11340, DF, Mexico
Gomez-Chavez, Fernando:
Escuela Nacl Med & Homeopatia ENMyH IPN, Dept Disciplinary Basic Format, Mexico City 07320, DF, Mexico
Inst Nacl Pediat, Lab Expt Immunol, Secretaria Salud & Catedras CONACyT, Mexico City 04530, DF, Mexico
Rodriguez-Martinez, Sandra:
Inst Politecn Nacl IPN, Escuela Nacl Ciencias Biol ENCB, Dept Immunol, Lab Innate Immunol, Rd Plan Ayala & Prolongac Carpio, Mexico City 11340, DF, Mexico
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