Genetic variations associated with pharmacoresistant epilepsy (Review)
Por:
Cárdenas-Rodríguez N., Carmona-Aparicio L., Pérez-Lozano D.L., Ortega-Cuellar D., Gómez-Manzo S., Ignacio-Mejía I.
Publicada:
1 ene 2020
Resumen:
Epilepsy is a common, serious neurological disorder worldwide. Although this disease can be successfully treated in most cases, not all patients respond favorably to medical treatments, which can lead to pharmacoresistant epilepsy. drug-resistant epilepsy can be caused by a number of mechanisms that may involve environmental and genetic factors, as well as disease- and drug-related factors. In recent years, numerous studies have demonstrated that genetic variation is involved in the drug resistance of epilepsy, especially genetic variations found in drug resistance-related genes, including the voltage-dependent sodium and potassium channels genes, and the metabolizer of endogenous and xenobiotic substances genes. The present review aimed to highlight the genetic variants that are involved in the regulation of drug resistance in epilepsy; a comprehensive understanding of the role of genetic variation in drug resistance will help us develop improved strategies to regulate drug resistance efficiently and determine the pathophysiological processes that underlie this common human neurological disease. © 2020 Spandidos Publications. All rights reserved.
Filiaciones:
Cárdenas-Rodríguez N.:
Laboratory of Neuroscience, National Institute of Pediatrics, Ministry of Health, Av. Insurgentes Sur 3700 Letra c, Insurgentes-Cuicuilco, Coyoacán, Mexico City, 04530, Mexico
Carmona-Aparicio L.:
Laboratory of Neuroscience, National Institute of Pediatrics, Ministry of Health, Av. Insurgentes Sur 3700 Letra c, Insurgentes-Cuicuilco, Coyoacán, Mexico City, 04530, Mexico
Pérez-Lozano D.L.:
Laboratory of Neuroscience, National Institute of Pediatrics, Ministry of Health, Av. Insurgentes Sur 3700 Letra c, Insurgentes-Cuicuilco, Coyoacán, Mexico City, 04530, Mexico
Department of Postgraduate of Medical, Dental and Health Sciences, Clinical Experimental Health Research, National Autonomous University of Mexico, Mexico City, 04510, Mexico
Ortega-Cuellar D.:
Laboratories of Experimental Nutrition, National Institute of Pediatrics, Ministry of Health, Coyoacán, Mexico City, 04530, Mexico
Gómez-Manzo S.:
Laboratories of Genetic Biochemistry, National Institute of Pediatrics, Ministry of Health, Coyoacán, Mexico City, 04530, Mexico
Ignacio-Mejía I.:
Laboratory of Translational Medicine, Military School of Health Graduates, Lomas De Sotelo, Militar, Mexico City, 11200, Mexico
Section of Research and Graduate Studies, Superior School of Medicine, National Polytechnic Institute, Mexico City, 11340, Mexico
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