Low Serum Interleukin-6 Is a Differential Marker of Obesity-Related Metabolic Dysfunction in Women and Men
Por:
Mendez-Garcia, Lucia A., Cid-Soto, Miguel, Aguayo-Guerrero, Jose A., Carrero-Aguirre, Miguel, Trejo-Millan, Fernanda, Islas-Andrade, Sergio, Fragoso, Jose M., Olivos-Garcia, Alfonso, Escobedo, Galileo
Publicada:
1 mar 2020
Resumen:
There is scant information regarding the role of interleukin (IL)-6 in
obesity-related metabolic dysfunction in humans. Thus, we studied the
serum levels of IL-6 in normal weight, overweight, and obese subjects,
and examined associations of IL-6 with hyperglycemia, insulin
resistance, dyslipidemia, and systemic inflammation. One hundred three
women and men were included in the study. Anthropometric parameters,
blood glucose, insulin, total cholesterol, and triglycerides were
measured. Serum levels of tumor necrosis factor-alpha (TNF-alpha),
IL-10, and IL-6 were measured by enzyme-linked immunosorbent assay
(ELISA). One-way analysis of variance (ANOVA) showed a 2.5-fold
significant decrease in serum IL-6 in overweight and obese individuals
when compared with normal weight controls. Serum IL-6 exhibited
significant inverse correlations with body mass index (r = -0.39/P <
0.0001), waist circumference (r = -0.42/P < 0.001), blood glucose (r =
-0.40/P < 0.0001), triglycerides (r = -0.34/P < 0.0001), and TNF-alpha
(r = -0.48/P < 0.0001), whereas a strongly positive correlation was
found with IL-10 (r = 0.77/P < 0.0001). Multiple linear regression
analysis revealed that behavior of IL-6 was mainly influenced by IL-10
(beta = 0.28/P = 1.95 x 10(-6)), TNF-alpha (beta = -0.67/P = 0.0017),
and body fat percentage (beta = -5.95/P = 7.67 x 10(-5)) in women. In
contrast, IL-10 (beta = 0.37/P = 1.34 x 10(-9)), TNF-alpha (beta =
-0.85/P = 0.0005), and triglycerides (beta = 1.07/P = 0.0007) were major
influencing factors of IL-6 in men. This study demonstrates that IL-6 is
a marker of metabolic dysfunction that is differentially regulated in
obese women and men.
Filiaciones:
Mendez-Garcia, Lucia A.:
Gen Hosp Mexico Dr Eduardo Liceaga, Lab Prote & Metabol, Div Res, Mexico City 06726, DF, Mexico
Cid-Soto, Miguel:
Inst Nacl Med Genom SS, Immunogen & Metab Dis Lab, Mexico City, DF, Mexico
Aguayo-Guerrero, Jose A.:
Gen Hosp Mexico Dr Eduardo Liceaga, Lab Prote & Metabol, Div Res, Mexico City 06726, DF, Mexico
Carrero-Aguirre, Miguel:
Gen Hosp Mexico Dr Eduardo Liceaga, Lab Prote & Metabol, Div Res, Mexico City 06726, DF, Mexico
Trejo-Millan, Fernanda:
Gen Hosp Mexico Dr Eduardo Liceaga, Lab Prote & Metabol, Div Res, Mexico City 06726, DF, Mexico
Islas-Andrade, Sergio:
Gen Hosp Mexico Dr Eduardo Liceaga, Lab Prote & Metabol, Div Res, Mexico City 06726, DF, Mexico
Fragoso, Jose M.:
Inst Nacl Cardiol Ignacio Chavez, Dept Mol Biol, Mexico City, DF, Mexico
Olivos-Garcia, Alfonso:
Univ Nacl Autonoma Mexico, Unit Expt Med, Sch Med, Gen Hosp Mexico Dr Eduardo Liceaga, Mexico City, DF, Mexico
Escobedo, Galileo:
Gen Hosp Mexico Dr Eduardo Liceaga, Lab Prote & Metabol, Div Res, Mexico City 06726, DF, Mexico
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