Understanding cellular interactions with nanomaterials: towards a rational design of medical nanodevices
Por:
Villanueva-Flores, Francisca, Castro-Lugo, Andres, Ramirez, Octavio T., Palomares, Laura A.
Publicada:
27 mar 2020
Resumen:
Biomedical applications increasingly require fully characterized new
nanomaterials. There is strong evidence showing that nanomaterials not
only interact with cells passively but also actively, mediating
essential molecular processes for the regulation of cellular functions,
but we are only starting to understand the mechanisms of those
interactions. Systematic studies about cell behavior as a response to
specific nanoparticle properties are scarce in the literature even when
they are necessary for the rational design of medical nanodevices.
Information in the literature shows that the physicochemical properties
determine the bioactivity, biocompatibility, and safety of
nanomaterials. The information available regarding the interaction and
responses of cells to nanomaterials has not been analyzed and discussed
in a single document. Hence, in this review, we present the latest
advances about cellular responses to nanomaterials and integrate the
available information into concrete considerations for the development
of innovative, efficient, specific and, more importantly, safe
biomedical nanodevices. We focus on how physicochemical nanoparticle
properties (size, chemical surface, shape, charge, and topography)
influence cell behavior in a first attempt to provide a practical guide
for designing medical nanodevices, avoiding common experimental
omissions that may lead to data misinterpretation. Finally, we emphasize
the importance of the systematic study of nano-bio interactions to
acquire sufficient reproducible information that allows accurate control
of cell behavior based on tuning of nanomaterial properties. This
information is useful to guide the design of specific nanodevices and
nanomaterials to elicit desired cell responses, like targeting, drug
delivery, cell attachment, differentiation, etc, or to avoid undesired
side effects.
Filiaciones:
Villanueva-Flores, Francisca:
Instituto de Biotecnología, Universidad Nacional Autónoma de México, Ave. Universidad 2001., Col. Chamilpa. Cuernavaca Morelos, 62210, Mexico
Univ Nacl Autonoma Mexico, Inst Biotecnol, Ave Univ 2001 Col Chamilpa, Cuernavaca 62210, Morelos, Mexico
Castro-Lugo, Andres:
Instituto de Biotecnología, Universidad Nacional Autónoma de México, Ave. Universidad 2001., Col. Chamilpa. Cuernavaca Morelos, 62210, Mexico
Univ Nacl Autonoma Mexico, Inst Biotecnol, Ave Univ 2001 Col Chamilpa, Cuernavaca 62210, Morelos, Mexico
Ramirez, Octavio T.:
Instituto de Biotecnología, Universidad Nacional Autónoma de México, Ave. Universidad 2001., Col. Chamilpa. Cuernavaca Morelos, 62210, Mexico
Univ Nacl Autonoma Mexico, Inst Biotecnol, Ave Univ 2001 Col Chamilpa, Cuernavaca 62210, Morelos, Mexico
Palomares, Laura A.:
Instituto de Biotecnología, Universidad Nacional Autónoma de México, Ave. Universidad 2001., Col. Chamilpa. Cuernavaca Morelos, 62210, Mexico
Univ Nacl Autonoma Mexico, Inst Biotecnol, Ave Univ 2001 Col Chamilpa, Cuernavaca 62210, Morelos, Mexico
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