Sex differences in brain gene expression among suicide completers
Por:
Cabrera-Mendoza, Brenda, Fresno, Cristobal, Monroy-Jaramillo, Nancy, Fries, Gabriel Rodrigo, Walss-Bass, Consuelo, Glahn, David C., Ostrosky-Wegman, Patricia, Mendoza-Morales R.C., Garcia-Dolores, Fernando, Díaz-Otañez C.E., González-Sáenz E.E., Genis-Mendoza A.D., Martínez-Magaña J.J., Romero-Pimentel A.L., Flores, Gonzalo, Vázquez-Roque R.A., Nicolini, Humberto
Publicada:
1 ene 2020
Resumen:
Background: Suicide rates vary substantially by sex. Suicides committed by males significantly outnumber female suicides. Disparities in community and social factors provide a partial explanation for this phenomenon. Thus, the evaluation of sex differences at a biological level might contribute to the elucidation of the factors involved in this imbalance. The aim of the present study was to evaluate sex-specific gene expression patterns in the suicidal brain. Methods: postmortem samples from the dorsolateral prefrontal cortex (DLPFC) of 75 Latino individuals were analyzed. We considered the following groups: i) male suicides (n = 38), ii) female suicides (n = 10), iii) male controls (n = 20), and iv) female controls (n = 7). Gene expression profiles were evaluated by microarrays. Differentially expressed genes among the groups were identified with a linear model. Similarities and differences in the gene sets between the sexes were identified. Results: Differentially expressed genes were identified between suicides and controls of each sex: 1,729 genes in females and 1,997 genes in males. Female-exclusive suicide genes were related to cell proliferation and immune response. Meanwhile, male-exclusive suicide genes were associated to DNA binding and ribonucleic protein complex. Sex-independent suicide genes showed enrichment in mitochondrial and vesicular functions. Limitations: Relatively small sample size. Our diagnosis approach was limited to information found on coroner's records. The analysis was limited to a single brain area (DLPFC) and we used microarrays. Conclusion: Previously unexplored sex differences in the brain gene expression of suicide completers were identified, providing valuable foundation for the evaluation of sex-specific factors in suicide. © 2020 Elsevier B.V.
Filiaciones:
Cabrera-Mendoza, Brenda:
Genomics of Psychiatric and Neurodegenerative Diseases Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City, Mexico
PECEM, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico
Natl Inst Genom Med INMEGEN, Genom Psychiat & Neurodegenerat Dis Lab, Periferico Sur 4809, Mexico City 14610, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Med, PECEM, Mexico City, DF, Mexico
Fresno, Cristobal:
Technological Development Department, National Institute of Genomic Medicine (INMEGEN), Mexico City, Mexico
Natl Inst Genom Med INMEGEN, Technol Dev Dept, Mexico City, DF, Mexico
Monroy-Jaramillo, Nancy:
Department of Genetics, National Institute of Neurology and Neurosurgery, Mexico City, Mexico
Natl Inst Neurol & Neurosurg, Dept Genet, Mexico City, DF, Mexico
Fries, Gabriel Rodrigo:
Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at HoustonTX, United States
Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
Walss-Bass, Consuelo:
Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at HoustonTX, United States
Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
Glahn, David C.:
Tommy Fuss Center for Neuropsychiatric Disease Research, Boston Children's Hospital, Boston, MA, United States
Harvard Medical School, Boston, MA, United States
Boston Childrens Hosp, Tommy Fuss Ctr Neuropsychiat Dis Res, Boston, MA USA
Harvard Med Sch, Boston, MA 02115 USA
Ostrosky-Wegman, Patricia:
Biomedical Research Institute, National Autonomous University of Mexico, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Biomed Res Inst, Mexico City, DF, Mexico
Mendoza-Morales R.C.:
Institute of Forensic Sciences (INCIFO), Mexico City, Mexico
Garcia-Dolores, Fernando:
Institute of Forensic Sciences (INCIFO), Mexico City, Mexico
Inst Forens Sci INCIFO, Mexico City, DF, Mexico
Díaz-Otañez C.E.:
Institute of Forensic Sciences (INCIFO), Mexico City, Mexico
González-Sáenz E.E.:
Psychiatric Hospital Fray Bernardino Alvarez, Mexico City, Mexico
Genis-Mendoza A.D.:
Genomics of Psychiatric and Neurodegenerative Diseases Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City, Mexico
Martínez-Magaña J.J.:
Genomics of Psychiatric and Neurodegenerative Diseases Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City, Mexico
Romero-Pimentel A.L.:
Genomics of Psychiatric and Neurodegenerative Diseases Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City, Mexico
Flores, Gonzalo:
Neuropsychiatry Laboratory, Institute of Physiology, Meritorious Autonomous University of Puebla, Mexico City, Mexico
Meritorious Autonomous Univ Puebla, Inst Physiol, Neuropsychiat Lab, Mexico City, DF, Mexico
Vázquez-Roque R.A.:
Neuropsychiatry Laboratory, Institute of Physiology, Meritorious Autonomous University of Puebla, Mexico City, Mexico
Nicolini, Humberto:
Genomics of Psychiatric and Neurodegenerative Diseases Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City, Mexico
Natl Inst Genom Med INMEGEN, Genom Psychiat & Neurodegenerat Dis Lab, Periferico Sur 4809, Mexico City 14610, DF, Mexico
Psychiat Hosp Fray Bernardino Alvarez, Mexico City, DF, Mexico
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