ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans
Por:
Boekstegers, Felix, Marcelain, Katherine, Barahona Ponce, Carol, Baez Benavides, Pablo F., Müller B., de Toro, Gonzalo, Retamales, Javier, Barajas, Olga, Ahumada, Monica, Morales, Erik, Rojas, Armando, Sanhueza, Veronica, Loader, Denisse, Rivera M.T., Gutierrez, Lorena, Bernal, Giuliano, Ortega, Alejandro, Montalvo, Domingo, Portiño S., Bertrán M.E., Gabler, Fernando, Spencer, Loreto, Olloquequi, Jordi, Gonzalez Silos, Rosa, Fischer, Christine, Scherer, Dominique, Jenab, Mazda, Aleksandrova, Krasimira, Katzke, Verena, Weiderpass, Elisabete, Moradi, Tahereh, Fischer, Krista, Bossers, Willem, Brenner, Hermann, Hveem, Kristian, Eklund, Niina, Völker U., Waldenberger, Melanie, Fuentes Guajardo, Macarena, Gonzalez-Jose, Rolando, Bedoya, Gabriel, Bortolini, Maria C., Canizales, Samuel, Gallo, Carla, Ruiz Linares, Andres, Rothhammer, Francisco, Lorenzo Bermejo, Justo
Publicada:
1 ene 2020
Resumen:
Background: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence. Methods: This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication. Results: Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low. Conclusion: Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs. © 2020 The Authors
Filiaciones:
Boekstegers, Felix:
Statistical Genetics Group, Institute of Medical Biometry and Informatics, University of Heidelberg, Germany
Heidelberg Univ, Inst Med Biometry & Informat, Stat Genet Grp, Neuenheimer Feld 130-3, D-69120 Heidelberg, Germany
Marcelain, Katherine:
Department of Basic and Clinical Oncology, Medical Faculty, University of Chile, Chile
Univ Chile, Med Fac, Dept Basic & Clin Oncol, Santiago, Chile
Barahona Ponce, Carol:
Statistical Genetics Group, Institute of Medical Biometry and Informatics, University of Heidelberg, Germany
Department of Basic and Clinical Oncology, Medical Faculty, University of Chile, Chile
Heidelberg Univ, Inst Med Biometry & Informat, Stat Genet Grp, Neuenheimer Feld 130-3, D-69120 Heidelberg, Germany
Univ Chile, Med Fac, Dept Basic & Clin Oncol, Santiago, Chile
Baez Benavides, Pablo F.:
Department of Basic and Clinical Oncology, Medical Faculty, University of Chile, Chile
Univ Chile, Med Fac, Dept Basic & Clin Oncol, Santiago, Chile
Müller B.:
Servicio de Oncología Médica, Instituto Nacional del Cáncer, Santiago, Chile
de Toro, Gonzalo:
Servicio de Anatomía Patológica, Hospital de Puerto Montt, Puerto Montt, Chile
Hosp Puerto Montt, Serv Anat Patol, Puerto Montt, Chile
Retamales, Javier:
Servicio de Oncología Médica, Instituto Nacional del Cáncer, Santiago, Chile
Inst Nacl Canc, Serv Oncol Med, Santiago, Chile
Barajas, Olga:
Department of Basic and Clinical Oncology, Medical Faculty, University of Chile, Chile
Oncology, Hospital Clínico Universidad de Chile, Santiago, Chile
Univ Chile, Med Fac, Dept Basic & Clin Oncol, Santiago, Chile
Hosp Clin Univ Chile, Oncol, Santiago, Chile
Ahumada, Monica:
Department of Basic and Clinical Oncology, Medical Faculty, University of Chile, Chile
Oncology, Hospital Clínico Universidad de Chile, Santiago, Chile
Univ Chile, Med Fac, Dept Basic & Clin Oncol, Santiago, Chile
Hosp Clin Univ Chile, Oncol, Santiago, Chile
Morales, Erik:
Servicio de Anatomía Patológica, Hospital Regional, Talca, Chile
Hosp Reg, Serv Anat Patol, Talca, Chile
Rojas, Armando:
Biomedical Research Labs, Medicine Faculty, Catholic University of Maule, Talca, Chile
Catholic Univ Maule, Med Fac, Biomed Res Labs, Talca, Chile
Sanhueza, Veronica:
Servicio de Anatomía Patológica, Hospital Padre Hurtado, Santiago, Chile
Hosp Padre Hurtado, Serv Anat Patol, Santiago, Chile
Loader, Denisse:
Servicio de Anatomía Patológica, Hospital Padre Hurtado, Santiago, Chile
Hosp Padre Hurtado, Serv Anat Patol, Santiago, Chile
Rivera M.T.:
Servicio de Anatomía Patológica, Hospital del Salvador, Santiago, Chile
Gutierrez, Lorena:
Servicio de Anatomía Patológica, Hospital San Juan de Dios, Santiago, Chile
Hosp San Juan Dios, Serv Anat Patol, Santiago, Chile
Bernal, Giuliano:
Laboratory of Molecular and Cellular Biology of Cancer (CancerLab), Department of Biomedical Sciences, Faculty of Medicine, Universidad Católica del Norte, Coquimbo, Chile
Univ Catolica Norte, Fac Med, Dept Biomed Sci, Lab Mol & Cellular Biol Canc CancerLab, Coquimbo, Chile
Ortega, Alejandro:
Servicio de Anatomía Patológica, Hospital Regional, Arica, Chile
Hosp Reg, Serv Anat Patol, Arica, Chile
Montalvo, Domingo:
Department of Surgery, Hospital Juan Noe Crevani, Arica, Chile
Hosp Juan Noe Crevani, Dept Surg, Arica, Chile
Portiño S.:
Oncology, Hospital Clínico Universidad de Chile, Santiago, Chile
Bertrán M.E.:
Secretaría Regional Ministerial de Salud, Ministerio de Salud, Valdivia, Chile
Gabler, Fernando:
Servicio de Anatomía Patológica, Hospital San Borja Arriarán, Santiago, Chile
Hosp San Borja Arriaran, Serv Anat Patol, Santiago, Chile
Spencer, Loreto:
Servicio de Anatomía Patológica, Hospital Regional Guillermo Grant Benavente, Concepción, Chile
Hosp Reg Guillermo Grant Benavente, Serv Anat Patol, Concepcion, Chile
Olloquequi, Jordi:
Laboratory of Cellular and Molecular Pathology, Instituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca, Chile
Univ Autonoma Chile, Fac Ciencias Salud, Inst Ciencias Biomed, Lab Cellular & Mol Pathol, Talca, Chile
Gonzalez Silos, Rosa:
Statistical Genetics Group, Institute of Medical Biometry and Informatics, University of Heidelberg, Germany
Heidelberg Univ, Inst Med Biometry & Informat, Stat Genet Grp, Neuenheimer Feld 130-3, D-69120 Heidelberg, Germany
Fischer, Christine:
Institute of Human Genetics, University of Heidelberg, Germany
Heidelberg Univ, Inst Human Genet, Heidelberg, Germany
Scherer, Dominique:
Statistical Genetics Group, Institute of Medical Biometry and Informatics, University of Heidelberg, Germany
Heidelberg Univ, Inst Med Biometry & Informat, Stat Genet Grp, Neuenheimer Feld 130-3, D-69120 Heidelberg, Germany
Jenab, Mazda:
International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France
WHO, Int Agcy Res Canc IARC, Lyon, France
Aleksandrova, Krasimira:
Nutrition, Immunity and Metabolism Senior Scientist Group, Department of Nutrition and Gerontology, German, Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany, University of Potsdam, Institute of Nutritional Science, Potsdam, Germany
German Inst Human Nutr Potsdam Rehbruecke DIfE, Nutr Immun & Metab Senior Scientist Grp, Dept Nutr & Gerontol, Nuthetal, Germany
Univ Potsdam, Inst Nutr Sci, Potsdam, Germany
Katzke, Verena:
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany
Weiderpass, Elisabete:
International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France
WHO, Int Agcy Res Canc IARC, Lyon, France
Moradi, Tahereh:
Division of Epidemiology, Department of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Karolinska Inst, Dept Environm Med, Div Epidemiol, Stockholm, Sweden
Fischer, Krista:
Estonian Genome Centre, Institute of Genomics, University of Tartu, Estonia
Univ Tartu, Estonian Genome Ctr, Inst Genom, Tartu, Estonia
Bossers, Willem:
The Lifelines Cohort Study, Groningen, Netherlands
Lifelines Cohort Study, Groningen, Netherlands
Brenner, Hermann:
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), German Cancer Consortium (DKTK), Heidelberg, Germany
German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Div Prevent Oncol, Heidelberg, Germany
German Canc Consortium DKTK, Natl Ctr Tumor Dis NCT, Heidelberg, Germany
Hveem, Kristian:
The Nord-Trøndelag Health (HUNT) Research Centre, Norwegian University of Science and Technology (NTNU), K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway
Norwegian Univ Sci & Technol NTNU, Nord Trondelag Hlth HUNT Res Ctr, Trondheim, Norway
Norwegian Univ Sci & Technol, NTNU, Dept Publ Hlth & Nursing, KG Jebsen Ctr Genet Epidemiol, Trondheim, Norway
Eklund, Niina:
Genomics and biobank, National Institute for Health and Welfare (THL), Helsinki, Finland
Natl Inst Hlth & Welf THL, Genom & Biobank, Helsinki, Finland
Völker U.:
Interfakultäres Institut für Genetik und Funktionelle Genomforschung, Universitätsmedizin Greifswald, Germany
Waldenberger, Melanie:
Research Unit of Molecular Epidemiology and Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Neuherberg, Germany
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol, Neuherberg, Germany
Fuentes Guajardo, Macarena:
Instituto de Alta Investigación, Tarapacá University, Chile
Tarapaca Univ, Inst Alta Invest, Santiago, Chile
Gonzalez-Jose, Rolando:
Instituto Patagónico de Ciencias Sociales y Humanas, Centro Nacional Patagónico, CONICET, Puerto Madryn, Argentina
Consejo Nacl Invest Cient & Tecn, Inst Patagon Ciencias Sociales & Humanas, Ctr Nacl Patagon, Puerto Madryn, Argentina
Bedoya, Gabriel:
Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia, Medellín, Colombia
Univ Antioquia, Fac Ciencias Exactas & Nat, Medellin, Colombia
Bortolini, Maria C.:
Instituto De Biociências, Universidad Federal Do Rio Grande Do Sul, Puerto Alegre, Brazil
Univ Fed Rio Grande do Sul, Inst Biociencias, Puerto Alegre, Brazil
Canizales, Samuel:
Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Univ Nacl Autonoma Mexico, Fac Quim, Ciudad De Mexico, Mexico
Gallo, Carla:
Unidad de Neurobiología Molecular y Genética, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru
Univ Peruana Cayetano Heredia, Fac Ciencias & Filosofia, Labs Invest & Desarrollo, Unidad Neurobiol Mol & Genet, Lima, Peru
Ruiz Linares, Andres:
Ministry of Education Key Laboratory of Contemporary Anthropology and Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai 200433, China
Fudan Univ, Sch Life Sci, Key Lab Contemporary Anthropol, Minist Educ, Shanghai 200433, Peoples R China
Fudan Univ, Sch Life Sci, Collaborat Innovat Ctr Genet & Dev, Shanghai 200433, Peoples R China
Fudan Univ, Human Phenome Inst, Shanghai 200433, Peoples R China
Rothhammer, Francisco:
Instituto de Alta Investigación, Tarapacá University, Chile
Tarapaca Univ, Inst Alta Invest, Santiago, Chile
Lorenzo Bermejo, Justo:
Statistical Genetics Group, Institute of Medical Biometry and Informatics, University of Heidelberg, Germany
Heidelberg Univ, Inst Med Biometry & Informat, Stat Genet Grp, Neuenheimer Feld 130-3, D-69120 Heidelberg, Germany
Hosp Salvador, Serv Anat Patol, Santiago, Chile
Minist Salud, Secretaria Reg Minist Salud, Valdivia, Chile
Univ Med Greifswald, Interfak Inst Genet & Funkt Genomforsch, Greifswald, Germany
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