First report on natural infection with Leishmania infantum in a domestic ferret (Mustela putorius furo) in Spain


Por: Giner J., Basurco A., Alcover M.M., Riera C., Fisa R., López R.A., Juan-Sallés C., Verde M.T., Fernández A., Yzuel A., Villanueva-Saz S.

Publicada: 1 ene 2020
Resumen:
A pet domestic ferret (Mustela putorius furo) with a papular lesion involving the right pinna was diagnosed with chronic pyogranulomatous dermatitis by histopathologic examination. Intralesional, intracytoplasmic oval microorganisms compatible with Leishmania spp. or Histoplasma spp. were observed in macrophages and multinucleate giant cells. Leishmania infantum (L. infantum) infection was diagnosed by PCR, culture in Novy-MacNeal-Nicolle medium, and immunohistochemistry. Abnormal clinicopathological results included increased alanine transferase, alkaline phosphatase, serum gamma glutamyl transferase and polyclonal gammpathy. Anti-Leishmania antibodies were detected by enzyme-linked immunosorbent assay, immunofluorescence antibody test and western blot using L. infantum antigen. Immunoreactivity against the 16 kDa specific L. infantum antigen fraction was observed by western blot. PCR performed in blood samples obtained from this patient after positive parasite isolation detected L. infantum DNA. To the authors' knowledge, this is the first diagnosis and isolation of L. infantum in a domestic ferret naturally infected in an endemic region (Spain) where canine and feline leishmaniosis is frequently detected. According to these findings, ferrets should be included as potential reservoir hosts of L. infantum. Future investigations should analyze the epidemiological role of ferrets in L. infantum infection including the prevalence of infection. © 2020 Elsevier B.V.

Filiaciones:
Giner J.:
 Menescalia Veterinary Clinic, Ismael Merlo Actor, 5, Valencia, 46020, Spain

Basurco A.:
 Animal Pathology Department, Veterinary Faculty, University of Zaragoza, Miguel Servet 177, Zaragoza, 50013, Spain

Alcover M.M.:
 Laboratory of Parasitology, Pharmacy Faculty, University of Barcelona, Avda. Joan XXIII s/n, Barcelona, 08028, Spain

Riera C.:
 Laboratory of Parasitology, Pharmacy Faculty, University of Barcelona, Avda. Joan XXIII s/n, Barcelona, 08028, Spain

Fisa R.:
 Laboratory of Parasitology, Pharmacy Faculty, University of Barcelona, Avda. Joan XXIII s/n, Barcelona, 08028, Spain

López R.A.:
 Department of Pathology, Faculty of Veterinary Medicine and Zootechnics, National Autonomous University of Mexico, Ciudad Universitaria, Ave. Universidad 3000, Circuito Exterior, Coyoacan, Mexico City, CP 04510, Mexico

 Aquapath. Laboratory of Veterinary Anatomic Pathology, Residencial Valle Verde, Monte Carpatos #58, Colima, CP 28610, Mexico

Juan-Sallés C.:
 Arquitecto Santiago Pérez Aracil 30 bajo (centro veterinario), Noah's Path, Elche, 03203, Spain

Verde M.T.:
 Animal Pathology Department, Veterinary Faculty, University of Zaragoza, Miguel Servet 177, Zaragoza, 50013, Spain

 Clinical Immunology Laboratory, Veterinary Faculty, University of Zaragoza, Miguel Servet 177, Zaragoza, 50013, Spain

Fernández A.:
 Animal Pathology Department, Veterinary Faculty, University of Zaragoza, Miguel Servet 177, Zaragoza, 50013, Spain

 Clinical Immunology Laboratory, Veterinary Faculty, University of Zaragoza, Miguel Servet 177, Zaragoza, 50013, Spain

Yzuel A.:
 Clinical Immunology Laboratory, Veterinary Faculty, University of Zaragoza, Miguel Servet 177, Zaragoza, 50013, Spain

Villanueva-Saz S.:
 Clinical Immunology Laboratory, Veterinary Faculty, University of Zaragoza, Miguel Servet 177, Zaragoza, 50013, Spain

 Department of Pharmacology and Physiology, Veterinary Faculty, University of Zaragoza, Miguel Servet 177, Zaragoza, 50013, Spain
ISSN: 24059390
Editorial
Elsevier B.V., RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS, Países Bajos
Tipo de documento: Article
Volumen: 19 Número:
Páginas:
WOS Id: 000592486200018

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