Design and evaluation of pH-dependent nanosystems based on cellulose acetate phthalate, nanoparticles loaded with chlorhexidine for periodontal treatment
Por:
Vidal-Romero, Gustavo, Zambrano-Zaragoza, Maria L., Martinez-Acevedo, Lizbeth, Leyva-Gomez, Gerardo, Mendoza-Elvira, Susana E., Quintanar-Guerrero, David
Publicada:
1 ene 2019
Categoría:
Pharmaceutical science
Resumen:
This work aimed to develop and evaluate pH-dependent systems based on nanospheres (NSphs) and nanocapsules (NCs) loaded with chlorhexidine (CHX) base as a novel formulation for the treatment of periodontal disease. Cellulose acetate phthalate (CAP) was employed as a pH-dependent polymeric material. The NSphs and NCs were prepared using the emulsion-diffusion technique and then characterized according to encapsulation efficiency (EE), size, zeta-potential, morphology, thermal properties, release profiles and a preliminary clinical panel test. The formulations showed 77% and 61% EE and 57% and 84% process efficiency (PE), respectively. Both systems were spherical with an average size of 250–300 nm. Differential scanning calorimetry (DSC) studies showed that the drug has the potential to be dispersed molecularly in the NSph matrix or dissolved in the oily center of the NCs. The CHX release test revealed that the release of NSphs-CHX follows Fickian diffusion involving diffusion-erosion processes. The NCs showed a slower release than the NSphs, following non-Fickian diffusion, which is indicative of anomalous transport. These nanosystems may, therefore, be employed as novel formulations for treating periodontal disease, due to (1) their coverage of a large surface area, (2) the controlled release of active substances at different pH, and (3) potential gingival tissue infiltration. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Filiaciones:
Vidal-Romero, Gustavo:
Laboratorio de Posgrado en Tecnología Farmacéutica, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de MéxicoEstado de México C.P. 54745, Mexico
Univ Nacl Autonoma Mexico, Fac Estudios Super Cuautitlan, Lab Posgrad Tecnol Farmaceut, Mexico City 54745, Estado De Mexic, Mexico
Zambrano-Zaragoza, Maria L.:
Laboratorio de Procesos de Transformación y Tecnologías Emergentes de Alimentos, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de MéxicoEstado de Mexico CP 54714, Mexico
Univ Nacl Autonoma Mexico, Fac Estudios Super Cuautitlan, Lab Proc Transformac & Tecnol Emergentes Alimento, Mexico City 54714, Estado De Mexic, Mexico
Martinez-Acevedo, Lizbeth:
Laboratorio de Posgrado en Tecnología Farmacéutica, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de MéxicoEstado de México C.P. 54745, Mexico
Univ Nacl Autonoma Mexico, Fac Estudios Super Cuautitlan, Lab Posgrad Tecnol Farmaceut, Mexico City 54745, Estado De Mexic, Mexico
Leyva-Gomez, Gerardo:
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Ciudad De Mexico 04510, Mexico
Mendoza-Elvira, Susana E.:
Laboratorio de Virología, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de MéxicoEstado de México C.P. 54745, Mexico
Univ Nacl Autonoma Mexico, Fac Estudios Super Cuautitlan, Lab Virol, Ciudad De Mexico 54745, Estado De Mexic, Mexico
Quintanar-Guerrero, David:
Laboratorio de Posgrado en Tecnología Farmacéutica, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de MéxicoEstado de México C.P. 54745, Mexico
Univ Nacl Autonoma Mexico, Fac Estudios Super Cuautitlan, Lab Posgrad Tecnol Farmaceut, Mexico City 54745, Estado De Mexic, Mexico
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