Toward a papaya-based oral vaccine against cysticercosis
Por:
Rosales, S., Hernandez, M., Ortiz, A., Cervantes, J., Monreal, E., Villalobos, N., Figueroa, A., Flores, I, Ramirez-Aquino, R., Villarreal, M. L., Fragoso, G., Sciutto, E.
Publicada:
1 ene 2019
Categoría:
Horticulture
Resumen:
Cysticercosis, caused by Taenia solium, is a parasitic disease that
still affects human health and causes economic loss in underdeveloped
countries. Although various effective anti-cysticercosis vaccines have
been developed, they have not yet been extensively used in control
programs. The high cost and logistical difficulties of the available
injectable vaccine versions may account for this. Considering that
plant-based vaccines fulfill the requirements of low cost and
needle-free administration, a new effective oral anti-cysticercosis
vaccine expressed in papaya callus, named S3Pvac-papaya, was developed.
S3Pvac-papaya is composed of three peptides of 97, 18, and 12 amino
acids, and it provides high protection levels against cysticercosis when
orally administered to pigs. The vaccine can be reproduced in
outstanding amounts under controlled conditions, with similar content of
the recombinant peptides, in papaya callus cultivated on plates as well
as in cell suspension cultures. In addition, papaya is an attractive
host for vaccine production and delivery due to its activity against
intestinal parasites and its capacity to boost the general immunity
status. Therefore, we are currently working to extend the benefits of
our transgenic papaya lines by developing an oral anti-parasitic
supplement for livestock and pets, which is formulated with
untransformed papaya tissues as a source of anti-parasitic and
immunostimulatory compounds, that simultaneously administers the
S3Pvac-papaya vaccine to induce innate and adaptive immune responses.
Filiaciones:
Rosales, S.:
Laboratorio de Biofarmacéuticos recombinantes, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico
Hernandez, M.:
Instituto de Investigaciones Biomédicas, AP 70228, México, D.F., CP 04510, Mexico
Ortiz, A.:
Centro de Biotecnología, Facultad de Ciencias Agropecuarias, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico
Facultad de Ciencias Agropecuarias, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico
Cervantes, J.:
Instituto de Investigaciones Biomédicas, AP 70228, México, D.F., CP 04510, Mexico
Monreal, E.:
Laboratorio de Biofarmacéuticos recombinantes, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico
Villalobos, N.:
Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, CDMX, Mexico
Figueroa, A.:
Universidad Tecnológica del Mar del Estado de Guerrero, Marquelia, Gro., Mexico
Flores, I:
Facultad de Ciencias Agropecuarias, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico
Ramirez-Aquino, R.:
Universidad Nacional de Agricultura, Catacamas Olancho, Honduras
Villarreal, M. L.:
Centro de Biotecnología, Facultad de Ciencias Agropecuarias, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico
Facultad de Ciencias Agropecuarias, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico
Fragoso, G.:
Instituto de Investigaciones Biomédicas, AP 70228, México, D.F., CP 04510, Mexico
Sciutto, E.:
Instituto de Investigaciones Biomédicas, AP 70228, México, D.F., CP 04510, Mexico
|