EXPLORATORY ANALYSIS OF POLYGENIC RISK SCORES FOR PSYCHIATRIC DISORDERS: APPLIED TO DUAL DIAGNOSIS
Por:
Martinez-Magana, Jose J., Gonzalez-Castro, Thelma B., Genis-Mendoza, Alma D., Tovilla-Zarate, Carlos A., Juarez-Rojop, Isela E., Saucedo-Uribe, Erasmo, Rodriguez-Mayoral, Oscar, Lanzagorta, Nuria, Escamilla, Michael, Macias-Kauffer, Luis, Nicolini, Humberto
Publicada:
1 ene 2019
Categoría:
Medicine (miscellaneous)
Resumen:
Background: Concurrence of substance use disorders (SUDs) is high in individuals with psychiatric illnesses; more importantly, individuals with both disorders (dual diagnosis) have more severe symptoms. Psychiatric disorders have been proposed to share a genetic susceptibility with SUDs. To explore this shared genetic susceptibility, we analyzed whether any of the polygenic risk scores (PRSs) for psychiatric disorders could be associated to dual diagnosis in patients with schizophrenia (SCZ) or bipolar disorder (BD). Methods: We included 192 individuals of Mexican ancestry: 72 with SCZ, 53 with BD, and 67 unrelated controls without psychiatric disorders. We derived calculations of PRS for autism spectrum disorders, attention-deficit/hyperactive disorder, BD, major depression, and SCZ using summary genome-wide association statistics previously published. Results: We found that dual diagnosis had a shared genetic susceptibility with major depressive disorder (MDD) and SCZ; furthermore, in individuals with BD, dual diagnosis could be predicted by PRS for MDD. Conclusions: Our results reinforce the notion that individuals with dual diagnosis have a higher genetic susceptibility to develop both disorders. However, analyses of larger sample sizes are required to further clarify how to predict risks through PRS within different populations. Copyright: © 2019 Permanyer.
Filiaciones:
Martinez-Magana, Jose J.:
Academic Division of Health Sciences, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco, Mexico
Genomics Laboratory of Psychiatric and Neurodegenerative Diseases, Instituto Nacional de Medicina GenómicaMexico City, Mexico
Univ Juarez Autonoma Tabasco, Acad Div Hlth Sci, Villahermosa, Tabasco, Mexico
Inst Nacl Med Genom, Genom Lab Psychiat & Neurodegenerat Dis, Mexico City, DF, Mexico
Gonzalez-Castro, Thelma B.:
Academic Division of Health Sciences, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco, Mexico
Multidisciplinary Academic Division of Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Mexico
Univ Juarez Autonoma Tabasco, Acad Div Hlth Sci, Villahermosa, Tabasco, Mexico
Univ Juarez Autonoma Tabasco, Multidisciplinary Acad Div Jalpa de Mendez, Jalpa De Mendez, Mexico
Genis-Mendoza, Alma D.:
Genomics Laboratory of Psychiatric and Neurodegenerative Diseases, Instituto Nacional de Medicina GenómicaMexico City, Mexico
Hospital Psiquiátrico Infantil "Juan N. Navarro", Servicios de Atención PsiquiátricaMexico City, Mexico
Inst Nacl Med Genom, Genom Lab Psychiat & Neurodegenerat Dis, Mexico City, DF, Mexico
Hosp Psiquiatr Infantil Juan N Navarro, Servs Atenc Psiquiatr, Mexico City, DF, Mexico
Tovilla-Zarate, Carlos A.:
Multidisciplinary Academic Division of Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Mexico
Univ Juarez Autonoma Tabasco, Multidisciplinary Acad Div Comalcalco, Comalcalco, Mexico
Juarez-Rojop, Isela E.:
Academic Division of Health Sciences, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco, Mexico
Univ Juarez Autonoma Tabasco, Acad Div Hlth Sci, Villahermosa, Tabasco, Mexico
Saucedo-Uribe, Erasmo:
Neurosciences Center, Universidad Autónoma de Nuevo León, Monterrey, Mexico
Univ Autonoma Nuevo Leon, Neurosci Ctr, Monterrey, Mexico
Rodriguez-Mayoral, Oscar:
Palliative Care Unit, Instituto Nacional de CancerologíaMexico City, Mexico
Inst Nacl Cancerol, Palliat Care Unit, Mexico City, DF, Mexico
Lanzagorta, Nuria:
Grupo de Estudios Médicos y Familiares CarracciMexico City, Mexico
Grp Estudios Med & Familiares Carracci, Mexico City, DF, Mexico
Escamilla, Michael:
Department of Psychiatry and Center of Excellence in Neurosciences, Texas Tech University Health Sciences Center, El Paso, TX, United States
Texas Tech Univ, Hlth Sci Ctr, Dept Psychiat, El Paso, TX USA
Texas Tech Univ, Hlth Sci Ctr, Ctr Excellence Neurosci, El Paso, TX USA
Macias-Kauffer, Luis:
Unit of Population Genomics Applied to Health, Faculty of Chemistry, Universidad Nacional Autónoma de México - Instituto Nacional de Medicina GenómicaMexico City, Mexico
Univ Nacl Autonoma Mexico, Fac Chem, Inst Nacl Med Genom, Unit Populat Genom Appl Hlth, Mexico City, DF, Mexico
Nicolini, Humberto:
Genomics Laboratory of Psychiatric and Neurodegenerative Diseases, Instituto Nacional de Medicina GenómicaMexico City, Mexico
Grupo de Estudios Médicos y Familiares CarracciMexico City, Mexico
Inst Nacl Med Genom, Genom Lab Psychiat & Neurodegenerat Dis, Mexico City, DF, Mexico
Grp Estudios Med & Familiares Carracci, Mexico City, DF, Mexico
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