Micro-macro: Selective integration of microfeatures inside low-cost macromolds for PDMS microfluidics fabrication
Por:
Jimenez-Diaz, Edgar, Cano-Jorge, Mariel, Zamarron-Hernandez, Diego, Cabriales, Lucia, Paez-Larios, Francisco, Cruz-Ramirez, Aaron, Vazquez-Victorio, Genaro, Fiordelisio, Tatiana, Hautefeuille, Mathieu
Publicada:
1 ene 2019
Resumen:
Microfluidics has become a very promising technology in recent years, due to its great potential to revolutionize life-science solutions. Generic microfabrication processes have been progressively made available to academic laboratories thanks to cost-effective soft-lithography techniques and enabled important progress in applications like lab-on-chip platforms using rapid-prototyping. However, micron-sized features are required in most designs, especially in biomimetic cell culture platforms, imposing elevated costs of production associated with lithography and limiting the use of such devices. In most cases, however, only a small portion of the structures require high-resolution and cost may be decreased. In this work, we present a replica-molding method separating the fabrication steps of low (macro) and high (micro) resolutions and then merging the two scales in a single chip. The method consists of fabricating the largest possible area in inexpensive macromolds using simple techniques such as plastics micromilling, laser microfabrication, or even by shrinking printed polystyrene sheets. The microfeatures were made on a separated mold or onto existing macromolds using photolithography or 2-photon lithography. By limiting the expensive area to the essential, the time and cost of fabrication can be reduced. Polydimethylsiloxane (PDMS) microfluidic chips were successfully fabricated from the constructed molds and tested to validate our micro-macro method. © 2019 by the authors.
Filiaciones:
Facultad de Ciencias, Universidad Nacional Autónoma de México, CDMX, 04510, Mexico
Posgrado en Ciencias Biomédicas, Universidad Nacional Autónoma de México, CDMX, 04510, Mexico
Laboratorio Nacional de Soluciones Biomiméticas para Diagnostico y Terapia (LaNSBioDyT), Universidad Nacional Autónoma de México, CDMX, 04510, Mexico
Univ Nacl Autonoma Mexico, Fac Ciencias, Mexico City 04510, DF, Mexico
Univ Nacl Autonoma Mexico, Posgrad Ciencias Biomed, Mexico City 04510, DF, Mexico
Univ Nacl Autonoma Mexico, Lab Nacl Soluc Biomimet Diagnost & Terapia LaNSBi, Mexico City 04510, DF, Mexico
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