Curcumin Prevents Renal Dysfunction, Proteinaceous and Granular Cast Formation in Tubular Lumen in Kidney of Mice Exposed to Formaldehyde Inhalation
Por:
Trujillo, Joyce, Osorio-Chavez, Fanny, Noel Medina-Campos, Omar, Lilia Loredo, Maria, Pedraza-Chaverri, Jose, Arriaga, Sonia
Publicada:
1 ago 2019
Resumen:
Formaldehyde is a volatile chemical compound that is commonly used in
the chemical industry. Formaldehyde inhalation exposure has been
associated with cancer, respiratory diseases, digestive and neurological
disorders. Oxidative stress is one of the potential mechanisms by which
formaldehyde inhalation induces toxicity. Curcumin is a natural compound
endowed with antioxidant properties and my thus prevent
formaldehyde-induced toxicity. This study aimed to examine the effects
of formaldehyde inhalation on renal function and kidney structure of
mice; the potential protective effects of curcumin administration
against kidney dysfunction, renal damage and oxidative stress were also
investigated. Formaldehyde inhalation induced renal dysfunction and
damage, as shown by the increase of serum creatinine and blood urea
nitrogen levels, and caused histological damage associated with
proteinaceous and granular cast formation in renal tubular lumen. The
activity of antioxidant enzymes remained unchanged and malondialdehyde
levels increased in a discrete and statistically non-significant way.
Curcumin treatment prevented the above-described alterations by
preventing an increase in renal dysfunction and changes in the kidney
structure of mice. Therefore, curcumin can be a potentially useful
treatment against the effects induced by exposure to gaseous pollutants
such as formaldehyde in distal organs.
Filiaciones:
Trujillo, Joyce:
CONACYT, IPICYT, CIIDZA, San Luis Potosi 78216, Mexico
Osorio-Chavez, Fanny:
CONACYT, IPICYT, CIIDZA, San Luis Potosi 78216, Mexico
IPICYT, Div Ciencias Ambientales, San Luis Potosi 78216, Mexico
Noel Medina-Campos, Omar:
UNAM, Fac Quim, Dept Biol, Ciudad De Mexico 04510, Mexico
Lilia Loredo, Maria:
Univ Panamer, Escuela Med, Ciudad De Mexico 03920, Mexico
Pedraza-Chaverri, Jose:
UNAM, Fac Quim, Dept Biol, Ciudad De Mexico 04510, Mexico
Arriaga, Sonia:
CONACYT, IPICYT, CIIDZA, San Luis Potosi 78216, Mexico
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