Frequency of BRAF V600E Mutation in the Mexican Population of Patients With Metastatic Melanoma
Por:
Ruiz-Garcia, Erika, Matus-Santos, Juan A., Alberto Guadarrama-Orozco, Jorge, Angel Alvarez-Avitia, Miguel, Luis Aguilar-Ponce, Jose, Fernandez-Figueroa, Edith, Maldonado-Mendoza, Jessica, Lopez-Camarillo, Cesar, Marchat, Laurence A., Lino-Silva, Saul, Cuellar-Hubbe, Mario, de la Garza-Salazar, Jamie, Meneses-Garcia, Abelardo, Astudillo-de la Vega, Horacio, Martinez-Said, Hector
Publicada:
12 jun 2017
Categoría:
Medicine (miscellaneous)
Resumen:
Purpose The BRAF V600E mutation has been described in melanomas
occurring in the Caucasian, European, and Asian populations. However, in
the Mexican population, the status and clinical significance of BRAF
mutation has not been researched on a large scale.
Methods Consecutive BRAF-tested Mexican patients with metastatic
melanoma (n=127) were analyzed for mutations in exon 15 of the BRAF gene
in genomic DNA by real-time polymerase chain reaction technology for
amplification and detection. The results were correlated with the
clinical-pathologic features and the prognosis of the patients.
Results The frequency of somatic mutation V600E within the BRAF gene was
54.6% (43 of 127 patients). Nodular melanoma was the most prevalent
subtype in our population, with BRAF mutations in 37.2% (16 of 55
patients). In contrast, superficial spread had a frequency of 18.6%
BRAF mutation (eight of 24). Other clinicopathologic features were
assessed to correlate with the mutation status.
Conclusion This study searched for the most prevalent BRAF V600E
mutation type in melanoma in a heterogeneous population from Mexico.
Nodular melanoma was found to be the most prevalent in metastatic
presentation and the presence of BRAF V600E mutation, perhaps related to
the mixed ancestry; in the north, ancestry is predominantly European and
in the south, it is predominantly Asian. The outcomes of the mutation
correlations were similar to those found in other populations. J Glob
Oncol 00. (C) 2017 by American Society of Clinical Oncology
Filiaciones:
Ruiz-Garcia, Erika:
Natl Canc Inst, Mexico City, DF, Mexico
Matus-Santos, Juan A.:
Natl Canc Inst, Mexico City, DF, Mexico
Alberto Guadarrama-Orozco, Jorge:
Natl Canc Inst, Mexico City, DF, Mexico
Angel Alvarez-Avitia, Miguel:
Natl Canc Inst, Mexico City, DF, Mexico
Luis Aguilar-Ponce, Jose:
Natl Canc Inst, Mexico City, DF, Mexico
Fernandez-Figueroa, Edith:
Natl Canc Inst, Mexico City, DF, Mexico
Maldonado-Mendoza, Jessica:
Natl Canc Inst, Mexico City, DF, Mexico
Lopez-Camarillo, Cesar:
Autonomous Univ Mexico City, Mexico City, DF, Mexico
Marchat, Laurence A.:
Natl Polytech Inst, Mexico City, DF, Mexico
Lino-Silva, Saul:
Natl Canc Inst, Mexico City, DF, Mexico
Cuellar-Hubbe, Mario:
Natl Canc Inst, Mexico City, DF, Mexico
de la Garza-Salazar, Jamie:
Natl Canc Inst, Mexico City, DF, Mexico
Meneses-Garcia, Abelardo:
Natl Canc Inst, Mexico City, DF, Mexico
Astudillo-de la Vega, Horacio:
Med Ctr Siglo XXI, Mexico City, DF, Mexico
Martinez-Said, Hector:
Natl Canc Inst, Mexico City, DF, Mexico
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