Long Non-Coding RNA and Acute Leukemia
Por:
Cruz-Miranda G.M., Hidalgo-Miranda A., Bárcenas-López D.A., Núñez-Enríquez J.C., Ramírez-Bello J., Mejía-Aranguré J.M., Jiménez-Morales S.
Publicada:
1 ene 2019
Resumen:
Acute leukemia (AL) is the main type of cancer in children worldwide. Mortality by this disease is high in developing countries and its etiology remains unanswered. Evidences showing the role of the long non-coding RNAs (lncRNAs) in the pathophysiology of hematological malignancies have increased drastically in the last decade. In addition to the contribution of these lncRNAs in leukemogenesis, recent studies have suggested that lncRNAs could be used as biomarkers in the diagnosis, prognosis, and therapeutic response in leukemia patients. The focus of this review is to describe the functional classification, biogenesis, and the role of lncRNAs in leukemogenesis, to summarize the evidence about the lncRNAs which are playing a role in AL, and how these genes could be useful as potential therapeutic targets.
Filiaciones:
Cruz-Miranda G.M.:
Programa de Doctorado, Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico
Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico
Hidalgo-Miranda A.:
Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City, 14610, Mexico
Inst Nacl Med Genom, Lab Genom Canc, Mexico City 14610, DF, Mexico
Bárcenas-López D.A.:
Programa de Doctorado, Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico
Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico
Núñez-Enríquez J.C.:
Unidad de Investigación Médica en Epidemiología Clínica, UMAE Hospital de Pediatría "Dr. Silvestre Frenk Freund", Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Mexico City, 06720, Mexico
Unidad de Investigación Médica en Epidemiología Clínica, UMAE Hospital de Pediatría “Dr, Silvestre Frenk Freund”, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, 06720, Mexico
Ramírez-Bello J.:
Unidad de Investigación en Enfermedades Metabólicas y Endócrinas, Hospital Juárez de México, Mexico City, 07760, Mexico
Hosp Juarez Mexico, Unidad Invest Enfermedades Metab & Endocrinas, Mexico City 07760, DF, Mexico
Mejía-Aranguré J.M.:
Coordinación de Investigación en Salud, Instituto Mexicano del Seguro Social, Mexico City, 06720, Mexico
Jiménez-Morales S.:
Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City, 14610, Mexico
Inst Nacl Med Genom, Lab Genom Canc, Mexico City 14610, DF, Mexico
Univ Nacl Autonoma Mexico, Ciencias Biol, Programa Doctorado, Mexico City 04510, DF, Mexico
UMAE Hosp Pediat Dr Silvestre Frenk Freund, Unidad Invest Med Epidemiol Clin, Ctr Med Nacl Siglo 21, Inst Mexicano Seguro Social, Mexico City 06720, DF, Mexico
Inst Mexicano Seguro Social, Coordinac Invest Salud, Mexico City 06720, DF, Mexico
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