Urinary tract infections, immunity, and vaccination
Por:
Luna-Pineda V.M., Ochoa S., Cruz-Córdova A., Cázares-Domínguez V., Vélez-González F., Hernández-Castro R., Xicohtencatl-Cortes J.
Publicada:
1 ene 2018
Categoría:
Pediatrics, perinatology and child health
Resumen:
Urinary tract infections (UTI) are considered one of the main causes of morbidity worldwide, and uropathogenic Escherichia coli (UPEC) is the causative agent associated with these infections. The high morbidity produced by the UTI and the limitation of antibiotic treatments promotes the search for new alternatives against these infections. The knowledge that has been generated regarding the immune response in the urinary tract is important for the development of effective strategies in the UTI prevention, treatment, and control. Molecular biology and bioinformatics tools have allowed the construction of fusion proteins as biomolecules for the development of a viable vaccine against UTI. The fimbrial adhesins (FimH, CsgA, and PapG) of UPEC are virulence factors that contribute to the adhesion, invasion, and formation of intracellular bacterial communities. The generation of recombinant proteins from fimbrial adhesins as a single molecule is obtained by fusion technology. A few in vivo and in vitro studies have shown that fusion proteins provide an efficient immune response and protection against UTI produced by UPEC. Intranasal immunization of immunogenic molecules has generated a response in the urinary tract mucosa compared with other routes of immunization. The objective of this review was to propose a vaccine designed against UTI caused by UPEC, describing the general scenario of the infection, the mechanism of pathogenicity of bacteria, and the immune response of the host. © 2018. Hospital Infantil de México Federico Gómez, published by Permanyer México SA de CV, all rights reserved.
Filiaciones:
Luna-Pineda V.M.:
Laboratorio de Investigación en Bacteriología Intestinal, Hospital Infantil de México Federico Gómez, Mexico City, Mexico
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico
Ochoa S.:
Laboratorio de Investigación en Bacteriología Intestinal, Hospital Infantil de México Federico Gómez, Mexico City, Mexico
Cruz-Córdova A.:
Laboratorio de Investigación en Bacteriología Intestinal, Hospital Infantil de México Federico Gómez, Mexico City, Mexico
Cázares-Domínguez V.:
Laboratorio de Investigación en Bacteriología Intestinal, Hospital Infantil de México Federico Gómez, Mexico City, Mexico
Vélez-González F.:
Laboratorio de Investigación en Bacteriología Intestinal, Hospital Infantil de México Federico Gómez, Mexico City, Mexico
Hernández-Castro R.:
Departamento de Ecología de Agentes Patógenos, Hospital General Dr. Manuel Gea González, Mexico City, Mexico
Xicohtencatl-Cortes J.:
Laboratorio de Investigación en Bacteriología Intestinal, Hospital Infantil de México Federico Gómez, Mexico City, Mexico
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