Association of RMND1/CCDC170–ESR1 single nucleotide polymorphisms with hip fracture and osteoporosis in postmenopausal women
Por:
Hidalgo-Bravo A., Parra-Torres A.Y., Casas-Avila L., Jimenez-Ortega R.F., Ramírez-Salazar E.G., Patiño N., Rivera-Paredez B., Salmerón J., Valdés-Flores M., Velázquez-Cruz R.
Publicada:
2 ene 2019
Ahead of Print:
1 ene 2018
Resumen:
Objective: This study aimed to investigate the association of seven single nucleotide polymorphisms (SNPs) on the RMND1, CCDC170, and ESR1 genes with osteoporosis or hip fracture in a postmenopausal Mexican population. Methods: We included a group of 400 postmenopausal women from the Health Workers Cohort Study from the Mexican Institute of Social Security. As a replication sample, we recruited 423 postmenopausal women from the National Institute of Rehabilitation. Demographic data were collected through a structured questionnaire. Bone mineral density was assessed using dual X-ray absorptiometry. Individuals were classified as normal, osteopenia, osteoporosis, and fracture, according to World Health Organization criteria. Genotyping was performed using predesigned TaqMan Probes. Linear regression analysis was used to investigate association. Results: All of the analyzed SNPs showed association with at least one of the phenotypes of the study groups. In addition, we observed a region with linkage disequilibrium within the ESR1 gene in all groups. Conclusion: This study shows that an association of the SNPs can exist with osteopenia, osteoporosis, or fragility fracture. Our results agree with data published elsewhere, supporting the potential of these loci for the identification of the population at risk. However, additional studies are required to determine the extent of this association for other geographic regions of Mexico. © 2018, © 2018 International Menopause Society.
Filiaciones:
Hidalgo-Bravo A.:
Department of Genetics, National Institute of Rehabilitation, Mexico City, Mexico
Natl Inst Rehabil, Dept Genet, Mexico City, DF, Mexico
Parra-Torres A.Y.:
Genomics of Bone Metabolism Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City, Mexico
Natl Inst Genom Med INMEGEN, Genom Bone Metab Lab, Perifer Sur 4809, Mexico City 14610, DF, Mexico
Casas-Avila L.:
Department of Genetics, National Institute of Rehabilitation, Mexico City, Mexico
Natl Inst Rehabil, Dept Genet, Mexico City, DF, Mexico
Jimenez-Ortega R.F.:
Genomics of Bone Metabolism Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City, Mexico
Natl Inst Genom Med INMEGEN, Genom Bone Metab Lab, Perifer Sur 4809, Mexico City 14610, DF, Mexico
Ramírez-Salazar E.G.:
Genomics of Bone Metabolism Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City, Mexico
National Council for Science and Technology (CONACYT) - Genomics of Bone Metabolism Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City, Mexico
Natl Inst Genom Med INMEGEN, Genom Bone Metab Lab, Perifer Sur 4809, Mexico City 14610, DF, Mexico
Natl Inst Genom Med INMEGEN, Natl Council Sci & Technol CONACYT, Genom Bone Metab Lab, Mexico City, DF, Mexico
Patiño N.:
Subdirection of Development of Clinical Applications, National Institute of Genomic Medicine (INMEGEN), Mexico City, Mexico
Rivera-Paredez B.:
Academic Unit in Epidemiological Research, Research Center in Policies, Population and Health, School of Medicine, National Autonomous University of Mexico, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Sch Med, Res Ctr Policies Populat & Hlth, Acad Unit Epidemiol Res, Mexico City, DF, Mexico
Salmerón J.:
Academic Unit in Epidemiological Research, Research Center in Policies, Population and Health, School of Medicine, National Autonomous University of Mexico, Mexico City, Mexico
Center for Population Health Research, National Institute of Public Health (INSP), Cuernavaca, Mexico
Univ Nacl Autonoma Mexico, Sch Med, Res Ctr Policies Populat & Hlth, Acad Unit Epidemiol Res, Mexico City, DF, Mexico
Natl Inst Publ Hlth INSP, Ctr Populat Hlth Res, Cuernavaca, Morelos, Mexico
Valdés-Flores M.:
Department of Genetics, National Institute of Rehabilitation, Mexico City, Mexico
Natl Inst Rehabil, Dept Genet, Mexico City, DF, Mexico
Velázquez-Cruz R.:
Genomics of Bone Metabolism Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City, Mexico
Natl Inst Genom Med INMEGEN, Genom Bone Metab Lab, Perifer Sur 4809, Mexico City 14610, DF, Mexico
Natl Inst Genom Med INMEGEN, Subdirect Dev Clin Applicat, Mexico City, DF, Mexico
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