Breast Cancer Metastasis: Are Cytokines Important Players during Its Development and Progression?
Por:
Méndez-García L.A., Nava-Castro K.E., Ochoa-Mercado T.D.L., Palacios-Arreola M.I., Ruiz-Manzano R.A., Segovia-Mendoza, Mariana, Solleiro-Villavicencio, Helena, Cazarez-Martinez, Cinthia, Morales-Montor, Jorge
Publicada:
1 ene 2019
Resumen:
In breast cancer, an uncontrolled cell proliferation leads to tumor formation and development of a multifactorial disease. Metastasis is a complex process that involves tumor spread to distant parts of the body from its original site. Metastatic dissemination represents the main physiopathology of cancer. Inter- and intracellular communication in all systems in vertebrates is mediated by cytokines, which are highly inducible, secretory proteins, produced not only by immune system cells, but also by endocrine and nervous system cells. It has become clear in recent years that cytokines, as well as their receptors are produced in the organisms under physiological and pathological conditions; recently, they have been closely related to breast cancer metastasis. The exact initiation process of breast cancer metastasis is unknown, although several hypotheses have emerged. In this study, we thoroughly reviewed the role of several cytokines in breast cancer metastasis. Data reviewed suggest that cytokines and growth factors are key players in the breast cancer metastasis induction. This knowledge must be considered with the aim to development of new therapeutic approaches to counter breast cancer metastasis. © Copyright 2019, Mary Ann Liebert, Inc.
Filiaciones:
Unidad de Medicina Experimental, Hospital General de México Dr. Eduardo Liceaga, México DF, Mexico
Laboratorio de Genotoxicología y Medicina Ambientales, Departamento de Ciencias Ambientales, Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México, México DF, Mexico
Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, Ciudad de México, 04510, Mexico
Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad Universitaria, México DF, Mexico
Hosp Gen Mexico Dr Eduardo Liceaga, Unidad Med Expt, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Ctr Ciencias Atmosfera, Dept Ciencias Ambientales, Lab Genotoxicol & Med Ambientales, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Inmunol, AP 70228, Mexico City 04510, DF, Mexico
Univ Nacl Autonoma Mexico, Dept Fisiol, Fac Med, Mexico City, DF, Mexico
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