Surveillance for the identification of cases of acute respiratory infection by enterovirus D68 in children in a tertiary level care hospital during 2014-2016
Por:
Estela Gamino-Arroyo, Ana, Luis Sanchez-Huerta, Jose, Elhain de la Garza-Lopez, Alicia, Parra-Ortega, Israel, Escobar-Escamilla, Noe, Mendieta-Condado, Edgar, Garces-Ayala, Fabiola, Barrera-Badillo, Gisela, Ernesto Ramirez-Gonzalez, Jose, Alberto Diaz-Quinonez, Jose, de la Rosa-Zamboni, Daniela
Publicada:
1 ene 2018
Categoría:
Pediatrics, perinatology and child health
Resumen:
Background: The reemergence of enterovirus D68 (EV-D68) infections in
the United States was reported from August-October 2014 (691 cases). In
Mexico. an outbreak at the National Institute of Respiratory Diseases
was reported (24 cases). The results of epidemiological surveillance of
Enterovirus sp. (EV) and other respiratory viruses in a national
pediatric tertiary care level hospital are presented. Methods: Following
the alert issued by the reemergence of EV-D68 in 2014, epidemiological
surveillance -which only detected respiratory viruses by PCR in patients
with influenza-like illness using nasopharyngeal swabs- expanded to
include children with asthma exacerbation or acute respiratory distress.
Positive samples to EV were confirmed and typed by sequencing.
Subsequent sequencing was used to obtain the complete viral genome.
Results: Of 1705 samples, 13 were positive to EV. Patients with EV
presented the following comorbidities: chronic lung disease (77%),
neoplastic disease (15,4%), allergic asthma/rhinitis (23%), recurrent
pneumonia (23%), and other (23%). Of the 13 samples positive for EV,
three were positive for EV-D68. These cases required invasive mechanical
ventilation, presented no neurological involvement and survived.
Conclusions: The impact of the population studied by EV-D68 was lower
than that reported in Mexico during the same period. Cases of EV-D68
infection had multiple comorbidities, but few pulmonary comorbidities.
which could explain the low attack rate. The epidemiological
surveillance and infection prevention system may have contained the
outbreak.
Filiaciones:
Estela Gamino-Arroyo, Ana:
Hosp Infantil Mexico Dr Federico Gomez, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Mexico City, DF, Mexico
Luis Sanchez-Huerta, Jose:
Hosp Infantil Mexico Dr Federico Gomez, Mexico City, DF, Mexico
Elhain de la Garza-Lopez, Alicia:
Hosp Infantil Mexico Dr Federico Gomez, Mexico City, DF, Mexico
Parra-Ortega, Israel:
Hosp Infantil Mexico Dr Federico Gomez, Mexico City, DF, Mexico
Escobar-Escamilla, Noe:
Inst Diagnost & Referencia Epidemiol InDRE Dr Man, Secretaria Salud, Ciudad De Mexico, Mexico
Mendieta-Condado, Edgar:
Inst Diagnost & Referencia Epidemiol InDRE Dr Man, Secretaria Salud, Ciudad De Mexico, Mexico
Garces-Ayala, Fabiola:
Inst Diagnost & Referencia Epidemiol InDRE Dr Man, Secretaria Salud, Ciudad De Mexico, Mexico
Barrera-Badillo, Gisela:
Inst Diagnost & Referencia Epidemiol InDRE Dr Man, Secretaria Salud, Ciudad De Mexico, Mexico
Ernesto Ramirez-Gonzalez, Jose:
Inst Diagnost & Referencia Epidemiol InDRE Dr Man, Secretaria Salud, Ciudad De Mexico, Mexico
Alberto Diaz-Quinonez, Jose:
Inst Diagnost & Referencia Epidemiol InDRE Dr Man, Secretaria Salud, Ciudad De Mexico, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Mexico City, DF, Mexico
de la Rosa-Zamboni, Daniela:
Hosp Infantil Mexico Dr Federico Gomez, Mexico City, DF, Mexico
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