Dengue viruses cluster antigenically but not as discrete serotypes
Por:
Katzelnick L.C., Fonville J.M., Gromowski G.D., Arriaga J.B., Green A., James S.L., Lau L., Montoya M., Wang C., Van Blargan L.A., Russell C.A., Thu H.M., Pierson T.C., Buchy P., Aaskov J.G., Muñoz-Jordán J.L., Vasilakis N., Gibbons R.V., Tesh R.B., Osterhaus A.D.M.E., Fouchier R.A.M., Durbin A., Simmons C.P., Holmes E.C., Harris E., Whitehead S.S., Smith D.J.
Publicada:
1 ene 2015
Resumen:
The four genetically divergent dengue virus (DENV) types are traditionally classified as serotypes. Antigenic and genetic differences among the DENV types influence disease outcome, vaccine-induced protection, epidemic magnitude, and viral evolution.We scharacterized antigenic diversity in the DENV types by antigenic maps constructed from neutralizing antibody titers obtained from African green monkeys and after human vaccination and natural infections. Genetically, geographically, and temporally, diverse DENV isolates clustered loosely by type, but we found that many are as similar antigenically to a virus of a different type as to some viruses of the same type. Primary infection antisera did not neutralize all viruses of the same DENV type any better than other types did up to 2 years after infection and did not show improved neutralization to homologous type isolates. That the canonical DENV types are not antigenically homogeneous has implications for vaccination and research on the dynamics of immunity, disease, and the evolution of DENV.
Filiaciones:
Katzelnick L.C.:
Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Downing Street, Cambridge, United Kingdom
World Health Organization (WHO) Collaborating Center for Modeling, Evolution, Control of Emerging Infectious Diseases, Cambridge, United Kingdom
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States
Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, United States
Fonville J.M.:
Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Downing Street, Cambridge, United Kingdom
World Health Organization (WHO) Collaborating Center for Modeling, Evolution, Control of Emerging Infectious Diseases, Cambridge, United Kingdom
Department of Viroscience, Erasmus MC, Rotterdam, Netherlands
Gromowski G.D.:
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States
Arriaga J.B.:
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States
Green A.:
Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, United States
James S.L.:
Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Downing Street, Cambridge, United Kingdom
World Health Organization (WHO) Collaborating Center for Modeling, Evolution, Control of Emerging Infectious Diseases, Cambridge, United Kingdom
Lau L.:
Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, United States
Montoya M.:
Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, United States
Wang C.:
Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, United States
Van Blargan L.A.:
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States
Russell C.A.:
Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
Thu H.M.:
Department of Medical Research, Ziwaka Road, Yangon, Myanmar
Pierson T.C.:
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States
Buchy P.:
Institut Pasteur in Cambodia, Réseau International des Instituts Pasteur, Phnom Penh, Cambodia
Aaskov J.G.:
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
Australian Army Malaria Institute, Brisbane, Australia
Muñoz-Jordán J.L.:
Dengue Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico
Vasilakis N.:
Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas, Medical Branch, Galveston, TX, United States
Center for Tropical Diseases, University of Texas, Medical Branch, Galveston, TX, United States
Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, United States
Gibbons R.V.:
Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Tesh R.B.:
Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas, Medical Branch, Galveston, TX, United States
Center for Tropical Diseases, University of Texas, Medical Branch, Galveston, TX, United States
Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, United States
Osterhaus A.D.M.E.:
Department of Viroscience, Erasmus MC, Rotterdam, Netherlands
Fouchier R.A.M.:
Department of Viroscience, Erasmus MC, Rotterdam, Netherlands
Durbin A.:
Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States
Simmons C.P.:
Oxford University, Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Viet Nam
Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
Holmes E.C.:
Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences, Sydney Medical School, University of Sydney, Sydney, Australia
Harris E.:
Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, United States
Whitehead S.S.:
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States
Smith D.J.:
Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Downing Street, Cambridge, United Kingdom
World Health Organization (WHO) Collaborating Center for Modeling, Evolution, Control of Emerging Infectious Diseases, Cambridge, United Kingdom
Department of Viroscience, Erasmus MC, Rotterdam, Netherlands
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