Enhanced antibacterial nanocomposite mats by coaxial electrospinning of polycaprolactone fibers loaded with Zn-based nanoparticles
Por:
Prado-Prone, Gina, Silva-Bermudez, Phaedra, Almaguer-Flores, Argelia, Garcia-Macedo, Jorge A., Garcia, Victor I., Rodil, Sandra E., Ibarra, Clemente, Velasquillo, Cristina
Publicada:
1 jul 2018
Resumen:
ZnO and Zn acetate nanoparticles were embedded in polycaprolactone coaxial-fibers and uniaxial-fibers matrices to develop potential antibacterial nanocomposite wound dressings (mats). Morphology, composition, wettability, crystallinity and fiber structure of mats were characterized. Antibacterial properties ofmats were tested against E. coli and S. aureus by turbidity and MTT assays. The effect of UVA illumination (prior to bacteria inoculation) on mats' antibacterial activity was also studied. Results showed that a coaxial-fibers design maintained nanoparticles distributed in the outer-shell of fibers and, in general, enhanced the antibacterial effect of the mats, in comparison to conventional uniaxial-fibersmats. Results indicated that mats simultaneously inhibited planktonic and biofilm bacterial growth by, probably, two main antibacterial mechanisms; 1) release of Zn2+ ions (mainly from Zn acetate nanoparticles) and 2) photocatalytic oxidative processes exerted by ZnO nanoparticles. Antibacterial properties of mats were significantly improved by coaxial-fibers design and exposure to UVA-light prior to bacteria inoculation. (C) 2018 Elsevier Inc. All rights reserved.
Filiaciones:
Prado-Prone, Gina:
Posgrado en Ciencia e Ingeniería de Materiales, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Unidad de Ingeniería de Tejidos, Terapia Celular y Medicina Regenerativa, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México, Mexico
Univ Nacl Autonoma Mexico, Posgrado Ciencia & Ingn Mat, Mexico City, DF, Mexico
Inst Nacl Rehabil Luis Guillermo Ibarra Ibarra, Unidad Ingn Tejidos Terapia Celular & Med Regener, Mexico City, DF, Mexico
Silva-Bermudez, Phaedra:
Unidad de Ingeniería de Tejidos, Terapia Celular y Medicina Regenerativa, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México, Mexico
Inst Nacl Rehabil Luis Guillermo Ibarra Ibarra, Unidad Ingn Tejidos Terapia Celular & Med Regener, Mexico City, DF, Mexico
Almaguer-Flores, Argelia:
División de Estudios de Posgrado e Investigación, Facultad de Odontología, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Univ Nacl Autonoma Mexico, Fac Odontol, Div Estudios Posgrad & Invest, Mexico City, DF, Mexico
Garcia-Macedo, Jorge A.:
Instituto de Fisica, Universidad Nacional Autónoma de México, Ciudad de Mexico, Mexico
Garcia, Victor I.:
División de Estudios de Posgrado e Investigación, Facultad de Odontología, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Univ Nacl Autonoma Mexico, Fac Odontol, Div Estudios Posgrad & Invest, Mexico City, DF, Mexico
Rodil, Sandra E.:
Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Univ Nacl Autonoma Mexico, Inst Fis, Mexico City, DF, Mexico
Ibarra, Clemente:
Unidad de Ingeniería de Tejidos, Terapia Celular y Medicina Regenerativa, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México, Mexico
Dirección General, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México, Mexico
Inst Nacl Rehabil Luis Guillermo Ibarra Ibarra, Unidad Ingn Tejidos Terapia Celular & Med Regener, Mexico City, DF, Mexico
Inst Nacl Rehabil Luis Guillermo Ibarra Ibarr, Direcc Gen, Mexico City, DF, Mexico
Velasquillo, Cristina:
Subdirección de Investigación Tecnológica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México, Mexico
Inst Nacl Rehabil Luis Guillermo Ibarra Ibarra, Subdirecc Invest Tecnol, Mexico City, DF, Mexico
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