Invasive methicillin-resistant Staphylococcus aureus USA500 strains from the U.S. Emerging Infections Program constitute three geographically distinct lineages
Por:
Frisch, M. B., Castillo-Ramirez, S., Petit, III, R. A., Farley, M. M., Ray, S. M., Albrecht, V. S., Limbago, B. M., Hernandez, J., See, I., Satola, S. W., Read, T. D.
Publicada:
1 may 2018
Resumen:
USA500 isolates are clonal complex 8 (CC8) Staphylococcus aureus strains closely related to the prominent community- and hospital-associated USA300 group. Despite being relatively understudied, USA500 strains cause a significant burden of disease and are the third most common methicillin-resistant S. aureus (MRSA) strains identified in the U.S. Emerging Infections Program (EIP) invasive S. aureus surveillance. To better understand the genetic relationships of the strains, we sequenced the genomes of 539 USA500 MRSA isolates from sterile site infections collected through the EIP between 2005 and 2013 in the United States. USA500 isolates fell into three major clades principally separated by their distribution across different U.S. regions. Clade C1 strains, found principally in the Northeast, were associated with multiple IS256 insertion elements in their genomes and higher levels of antibiotic resistance. C2 was associated with Southern states, and E1 was associated with Western states. C1 and C2 strains all shared a frameshift in the gene encoding AdsA surface-attached surface protein. We propose that the term "USA500" should be used for CC8 strains sharing a recent common ancestor with the C1, C2, and E1 strains but not in the USA300 group. © 2018 Frisch et al.
Filiaciones:
Frisch, M. B.:
Petit, R
Castillo-Ramirez, S.:
UNAM, Ctr Genom Sci, Cuernavaca, Morelos, Mexico
Farley, M. M.:
III , Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA 30303 USA
Atlanta VA Med Ctr, Decatur, GA USA
Ray, S. M.:
III , Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA 30303 USA
Albrecht, V. S.:
Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Limbago, B. M.:
Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Hernandez, J.:
Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
See, I.:
Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA
Satola, S. W.:
III , Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA 30303 USA
Read, T. D.:
III , Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA 30303 USA
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