What makes an effective Chagas disease vector? Factors underlying Trypanosoma cruzi-triatomine interactions
Por:
de Fuentes-Vicente, Jose A., Gutierrez-Cabrera, Ana E., Laura Flores-Villegas, A., Lowenberger, Carl, Benelli, Giovanni, Salazar-Schettino, Paz M., Cordoba-Aguilar, Alex
Publicada:
1 jul 2018
Resumen:
The Chagas disease is caused by the parasite Trypanosoma cruzi, which
infect blood-feeding triatomine bugs to finally reach mammal hosts.
Chagas disease is endemic in Latin America, and is ranked among the 13
neglected tropical diseases worldwide. Currently, an estimate of 7
million people is infected by T. cruzi, leading to about 22000 deaths
per year throughout the Americas. As occurs with other vectors, a major
question towards control programs is what makes a susceptible bug. In
this review, we focus on findings linked to insect gut structure and
microbiota, immunity, genetics, blood sources, abiotic factors (with
special reference to ambient temperature and altitude) to understand the
interactions occurring between T. cruzi and triatomine bugs, under a
co-evolutionary scenario. These factors lead to varying fitness benefits
and costs for bugs, explaining why infection in the insect takes place
and how it varies in time and space. Our analysis highlights that major
factors are gut components and microbiota, blood sources and
temperature. Although their close interaction has never been clarified,
knowledge reviewed here may help to boost the success of triatomine
control programs, reducing the use of insecticides.
Filiaciones:
de Fuentes-Vicente, Jose A.:
Univ Pablo Guardado Chavez, Libramiento Norte Oriente 3450, Tuxtla Gutierrez 29040, Chiapas, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Dept Microbiol & Parasitol, Ave Univ 3000,Ciudad Univ, Coyoacan 04510, DF, Mexico
Gutierrez-Cabrera, Ana E.:
Inst Nacl Salud Publ, Conacyt Ctr Invest Enfermedades Infecciosas, Ave Univ 655, Cuernavaca 62100, Morelos, Mexico
Laura Flores-Villegas, A.:
Univ Nacl Autonoma Mexico, Fac Med, Dept Microbiol & Parasitol, Ave Univ 3000,Ciudad Univ, Coyoacan 04510, DF, Mexico
Lowenberger, Carl:
Simon Fraser Univ, Dept Biol Sci, Burnaby, BC V5A 1S6, Canada
Benelli, Giovanni:
Univ Pisa, Dept Agr Food & Environm, Via Borghetto 80, I-56124 Pisa, Italy
Scuola Super Sant Anna, BioRobot Inst, Viale Rinaldo Piaggio 34, I-56025 Pisa, Italy
Salazar-Schettino, Paz M.:
Univ Nacl Autonoma Mexico, Fac Med, Dept Microbiol & Parasitol, Ave Univ 3000,Ciudad Univ, Coyoacan 04510, DF, Mexico
Cordoba-Aguilar, Alex:
Univ Nacl Autonoma Mexico, Inst Ecol, Dept Ecol Evolut, Apdo P 70-275,Ciudad Univ, Coyoacan 04510, DF, Mexico
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