Selective estrogen receptor modulators regulate dendritic spine plasticity in the hippocampus of male rats
Por:
González-Burgos I., Rivera-Cervantes M.C., Velázquez-Zamora D.A., Feria-Velasco A., Garcia-Segura L.M.
Publicada:
1 ene 2012
Resumen:
Some selective estrogen receptor modulators, such as raloxifene and tamoxifen, are neuroprotective and reduce brain inflammation in several experimental models of neurodegeneration. In addition, raloxifene and tamoxifen counteract cognitive deficits caused by gonadal hormone deprivation in male rats. In this study, we have explored whether raloxifene and tamoxifen may regulate the number and geometry of dendritic spines in CA1 pyramidal neurons of the rat hippocampus. Young adult male rats were injected with raloxifene (1mg/kg), tamoxifen (1mg/kg), or vehicle and killed 24h after the injection. Animals treated with raloxifene or tamoxifen showed an increased numerical density of dendritic spines in CA1 pyramidal neurons compared to animals treated with vehicle. Raloxifene and tamoxifen had also specific effects in the morphology of spines. These findings suggest that raloxifene and tamoxifen may influence the processing of information by hippocampal pyramidal neurons by affecting the number and shape of dendritic spines. © 2012 Ignacio Gonzlez-Burgos et al.
Filiaciones:
González-Burgos I.:
Centro de Investigacin Biomédica de Occidente Guadalajara, Jalisco 44340, Mexico
CUCBA, Universidad de Guadalajara Guadalajara, Jalisco 45100, Mexico
Rivera-Cervantes M.C.:
CUCBA, Universidad de Guadalajara Guadalajara, Jalisco 45100, Mexico
Velázquez-Zamora D.A.:
Centro de Investigacin Biomédica de Occidente Guadalajara, Jalisco 44340, Mexico
CUCBA, Universidad de Guadalajara Guadalajara, Jalisco 45100, Mexico
Feria-Velasco A.:
CUCBA, Universidad de Guadalajara Guadalajara, Jalisco 45100, Mexico
Garcia-Segura L.M.:
Instituto Cajal, CSIC, 28002 Madrid, Spain
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