Progress on the Use of Commercial Digital Optical Disc Units for Low-Power Laser Micromachining in Biomedical Applications
Por:
Cruz-Ramírez A., Sánchez-Olvera R., Zamarrón-Hernández D., Hautefeuille M., Cabriales L., Jiménez-Díaz E., Díaz-Bello B., López-Aparicio J., Pérez-Calixto D., Cano-Jorge M., Vázquez-Victorio G.
Publicada:
1 abr 2018
Resumen:
The development of organ-on-chip and biological scaffolds is currently
requiring simpler methods for microstructure biocompatible materials in
three dimensions, to fabricate structural and functional elements in
biomaterials, or modify the physicochemical properties of desired
substrates. Aiming at addressing this need, a low-power CD-DVD-Blu-ray
laser pickup head was mounted on a programmable three-axis
micro-displacement system in order to modify the surface of polymeric
materials in a local fashion. Thanks to a specially-designed method
using a strongly absorbing additive coating the materials of interest,
it has been possible to establish and precisely control processes useful
in microtechnology for biomedical applications. The system was upgraded
with Blu-ray laser for additive manufacturing and ablation on a single
platform. In this work, we present the application of these fabrication
techniques to the development of biomimetic cellular culture platforms
thanks to the simple integration of several features typically achieved
with traditional, less cost-effective microtechnology methods in one
step or through replica-molding. Our straightforward approach indeed
enables great control of local laser microablation or polymerization for
true on-demand biomimetic micropatterned designs in transparent polymers
and hydrogels and is allowing integration of microfluidics,
microelectronics, surface microstructuring, and transfer of superficial
protein micropatterns on a variety of biocompatible materials.
Filiaciones:
Facultad de Ciencias, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Ciudad Universitaria, Ciudad de Mexico, Mexico
Laboratorio Nacional de Soluciones Biomiméticas para Diagnóstico y Terapia LaNSBioDyT, Facultad de Ciencias, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Ciudad Universitaria, Ciudad de Mexico, Mexico
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