Genetic Diversity and Distribution of Blastocystis Subtype 3 in Human Populations, with Special Reference to a Rural Population in Central Mexico
Por:
Rojas-Velazquez, Liliana, Moran, Patricia, Serrano-Vazquez, Angelica, Fernandez, Leonardo D., Perez-Juarez, Horacio, Poot-Hernandez, Augusto C., Portillo, Tobias, Gonzalez, Enrique, Hernandez, Eric, Partida-Rodriguez, Oswaldo, Nieves-Ramirez, Miriam E., Magana, Ulises, Torres, Javier, Eguiarte, Luis E., Pinero, Daniel, Ximenez, Cecilia
Publicada:
1 ene 2018
Resumen:
Blastocystis subtype 3 (ST3) is a parasitic protist found in the digestive tract of symptomatic and asymptomatic humans around the world. While this parasite exhibits a high prevalence in the human population, its true geographic distribution and global genetic diversity are still unknown. This gap in knowledge limits the understanding of the spread mechanisms, epidemiology, and impact that this parasite has on human populations. Herein, we provided new data on the geographical distribution and genetic diversity of Blastocystis ST3 from a rural human population in Mexico. To do so, we collected and targeted the SSU-rDNA region in fecal samples from this population and further compared its genetic diversity and structure with that previously observed in populations of Blastocystis ST3 from other regions of the planet. Our analyses reveled that diversity of Blastocystis ST3 showed a high haplotype diversity and genetic structure to the world level; however, they were low in the Morelos population. The haplotype network revealed a common widespread haplotype from which the others were generated recently. Finally, our results suggested a recent expansion of the diversity of Blastocystis ST3 worldwide.
Filiaciones:
Rojas-Velazquez, Liliana:
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Dr Balmis 148, Mexico City 06726, DF, Mexico
Univ Nacl Autonoma Mexico, Unidad Posgrad, Circuito Posgrad S-N, Mexico City 04510, DF, Mexico
Moran, Patricia:
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Dr Balmis 148, Mexico City 06726, DF, Mexico
Serrano-Vazquez, Angelica:
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Dr Balmis 148, Mexico City 06726, DF, Mexico
Fernandez, Leonardo D.:
Univ Bernardo OHiggins, Ctr Invest Recursos Nat & Sustentabilidad CIRENYS, Ave Viel 1497, Santiago, Chile
Perez-Juarez, Horacio:
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Dr Balmis 148, Mexico City 06726, DF, Mexico
Univ Nacl Autonoma Mexico, Unidad Posgrad, Circuito Posgrad S-N, Mexico City 04510, DF, Mexico
Poot-Hernandez, Augusto C.:
Univ Nacl Autonoma Mexico, Inst Invest Matemat Aplicadas & Sistemas, Secc Ingn Sistemas Computac, Dept Ingn Sistemas Computac & Automat, Circuito Escolar 3000, Mexico City 04510, DF, Mexico
Portillo, Tobias:
Univ Nacl Autonoma Mexico, Inst Nacl Ciencias Med & Nutr, Red Apoyo Invest Coordinac Invest Cient, Unidad Bioinformat Bioestadist & Biol Computac, Vasco De Quiroga 15, Mexico City 14080, DF, Mexico
Gonzalez, Enrique:
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Dr Balmis 148, Mexico City 06726, DF, Mexico
Hernandez, Eric:
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Dr Balmis 148, Mexico City 06726, DF, Mexico
Partida-Rodriguez, Oswaldo:
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Dr Balmis 148, Mexico City 06726, DF, Mexico
Nieves-Ramirez, Miriam E.:
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Dr Balmis 148, Mexico City 06726, DF, Mexico
Magana, Ulises:
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Dr Balmis 148, Mexico City 06726, DF, Mexico
Univ Nacl Autonoma Mexico, Unidad Posgrad, Circuito Posgrad S-N, Mexico City 04510, DF, Mexico
Torres, Javier:
Hosp Pediat Mexico City, Ctr Med Siglo 21, IMSS, Unidad Invest Med Enfermedades Infecciosas & Para, Ave Cuauhtemoc 330, Mexico City 06720, DF, Mexico
Eguiarte, Luis E.:
Univ Nacl Autonoma Mexico, Inst Ecol, Dept Ecol Evolut, Circuito Exterior S-N, Mexico City 04510, DF, Mexico
Pinero, Daniel:
Univ Nacl Autonoma Mexico, Inst Ecol, Dept Ecol Evolut, Circuito Exterior S-N, Mexico City 04510, DF, Mexico
Ximenez, Cecilia:
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Dr Balmis 148, Mexico City 06726, DF, Mexico
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