Identification of Aspergillus tubingensis in a primary skin infection


Por: Frias-De-Leon, M. G., Rosas-de Paz, E., Arenas, R., Atoche, C., Duarte-Escalante, E., Molina de Soschin, D., Acosta-Altamirano, G., Reyes-Montes, M. R.

Publicada: 1 jun 2018 Ahead of Print: 1 ene 2018
Categoría: Infectious diseases

Resumen:
Objective. - Aspergillus section Nigri comprises a group of related species that include Aspergillus niger, A. welwitschiae, A. carbonarius, A. brasiliensis and A. tubingensis. Some of these species are morphologically very similar to A. niger but exhibit different patterns of susceptibility to antifungal agents; such is the case for A. tubingensis. Therefore, when diagnosing aspergillosis, it is important to identify the pathogen at the species level. This study aimed to identify the species of an Aspergillus spp. isolate (MM-82) obtained from a patient with a dermatosis localized to the right leg. Materials and methods. - The MM-82 isolate was examined for macro- and microscopic morphology, conidia size and thermotolerance, and a phylogenetic analysis of a benA gene segment was performed for molecular identification. Susceptibility to antifungals was determined using antifungal microdilution according to the methodology of European Society of Clinical Microbiology and Infectious Diseases (EUCAST). Results. - Based on its phenotypic characteristics and the phylogenetic analysis of the sequence of a benA gene segment, the MM-82 isolate was identified as A. tubingensis. This fungus did not show resistance to antifungal agents commonly used for treatment. Conclusion. - This study demonstrated that A. tubingensis can cause skin infection; this constitutes the first report of a case of aspergillosis caused by A. tubingensis in Mexico. (C) 2018 The Authors. Published by Elsevier Masson SAS.

Filiaciones:
Frias-De-Leon, M. G.:
 Hospital Regional de Alta Especialidad Ixtapaluca, Carretera Federal México–Puebla Km, 34.5, Pueblo de Zoquiapan, Ixtapaluca, Mexico

 Hosp Reg Alta Especialidad Ixtapaluca, Carretera Fed Mexico Puebla Km 34-5, Ixtapaluca 56530, Mexico

Rosas-de Paz, E.:
 Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria No. 3000, México Cd., Mx., Mexico

 UNAM, Fac Med, Dept Microbiol & Parasitol, Ciudad Univ 3000, Mexico Cd Mx 04510, Mexico

Arenas, R.:
 Departamento de Dermatología, Sección de Micología, Hospital General Dr. Manuel Gea González, México, Cd. Mx., Mexico

 Hosp Gen Dr Manuel Gea Gonzalez, Dept Dermatol, Secc Micol, Mexico Cd Mx, Mexico

Atoche, C.:
 Centro Dermatológico de Yucatán “Dr. Fernando Latapí”, Mérida, Yucatán, Mexico

 Ctr Dermatol Yucatan Dr Fernando Latapi, Merida, Yucatan, Mexico

Duarte-Escalante, E.:
 Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria No. 3000, México Cd., Mx., Mexico

 UNAM, Fac Med, Dept Microbiol & Parasitol, Ciudad Univ 3000, Mexico Cd Mx 04510, Mexico

Molina de Soschin, D.:
 Departamento de Dermatología, Sección de Micología, Hospital General Dr. Manuel Gea González, México, Cd. Mx., Mexico

 Hosp Gen Dr Manuel Gea Gonzalez, Dept Dermatol, Secc Micol, Mexico Cd Mx, Mexico

Acosta-Altamirano, G.:
 Hospital Regional de Alta Especialidad Ixtapaluca, Carretera Federal México–Puebla Km, 34.5, Pueblo de Zoquiapan, Ixtapaluca, Mexico

 Hosp Reg Alta Especialidad Ixtapaluca, Carretera Fed Mexico Puebla Km 34-5, Ixtapaluca 56530, Mexico

Reyes-Montes, M. R.:
 Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria No. 3000, México Cd., Mx., Mexico

 UNAM, Fac Med, Dept Microbiol & Parasitol, Ciudad Univ 3000, Mexico Cd Mx 04510, Mexico
ISSN: 11565233
Editorial
Elsevier Masson SAS, 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE, Francia
Tipo de documento: Article
Volumen: 28 Número: 2
Páginas: 274-278
WOS Id: 000440117300006
ID de PubMed: 29551443

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