Serum Levels of Interleukin-13 Increase in Subjects with Insulin Resistance but Do Not Correlate with Markers of Low-Grade Systemic Inflammation
Por:
Martinez-Reyes, Camilo P., Gomez-Arauz, Angelica Y., Torres-Castro, Israel, Manjarrez-Reyna, Aaron N., Palomera, Leon F., Olivos-Garcia, Alfonso, Mendoza-Tenorio, Edith, Sanchez-Medina, Gabriela A., Islas-Andrade, Sergio, Melendez-Mier, Guillermo, Escobedo, Galileo
Publicada:
1 ene 2018
Resumen:
Experimental evidence in mice suggests a role for interleukin- (IL-) 13
in insulin resistance and low-grade systemic inflammation. However,
IL-13 serum levels have not been assessed in subjects with insulin
resistance, and associations of IL-13 with parameters of low-grade
systemic inflammation are still unknown. Our main goal was to examine
the systemic levels of IL-13 in patients with insulin resistance, while
also studying the relationship of IL-13 with anthropometric, metabolic,
and low-grade systemic inflammatory markers. Ninety-two participants
were included in the study and divided into insulin-resistant patients
and noninsulin-resistant controls. Blood levels of IL-13, glucose,
insulin, triglycerides, cholesterol, tumor necrosis factor-alpha
(TNF-alpha), IL-10, proinflammatory (Mon-CD11c(+)CD206(-)), and
anti-inflammatory (Mon-CD11c(-)CD206(+)) monocytes, as well as
anthropometric parameters, were measured in all volunteers.
Insulin-resistant patients showed 2.5-fold higher serum levels of IL-13
than controls (P < 0.0001) and significantly increased values of
TNF-alpha and Mon-CD11c(+)CD206(-), with concomitant reductions in IL-10
and Mon-CD11c(-)CD206(+). Increased IL-13 was extraordinarily well
associated with hyperglycemia (r = 0.7362) and hypertriglyceridemia (r =
0.7632) but unexpectedly exhibited no significant correlations with
TNF-alpha (r = 0.2907), IL-10 (r = -0.3882), Mon-CD11c(+)CD206(-) (r =
0.2745) or Mon-CD11c(-)CD206(+) (r = 0.3237). This study demonstrates
that IL-13 serum levels are elevated in patients with insulin resistance
without showing correlation with parameters of low-grade systemic
inflammation.
Filiaciones:
Martinez-Reyes, Camilo P.:
Univ Nacl Autonoma Mexico, Sch Med, Unit Expt Med, Gen Hosp Mexico Dr Eduardo Liceaga, Mexico City 06726, DF, Mexico
Gomez-Arauz, Angelica Y.:
Univ Nacl Autonoma Mexico, Sch Med, Unit Expt Med, Gen Hosp Mexico Dr Eduardo Liceaga, Mexico City 06726, DF, Mexico
Torres-Castro, Israel:
Univ Nacl Autonoma Mexico, Sch Med, Unit Expt Med, Gen Hosp Mexico Dr Eduardo Liceaga, Mexico City 06726, DF, Mexico
Manjarrez-Reyna, Aaron N.:
Univ Nacl Autonoma Mexico, Sch Med, Unit Expt Med, Gen Hosp Mexico Dr Eduardo Liceaga, Mexico City 06726, DF, Mexico
Palomera, Leon F.:
Univ Nacl Autonoma Mexico, Sch Med, Unit Expt Med, Gen Hosp Mexico Dr Eduardo Liceaga, Mexico City 06726, DF, Mexico
Olivos-Garcia, Alfonso:
Univ Nacl Autonoma Mexico, Fac Med, Dept Med Expt, Mexico City 04510, DF, Mexico
Mendoza-Tenorio, Edith:
Univ Nacl Autonoma Mexico, Fac Med, Dept Med Expt, Mexico City 04510, DF, Mexico
Sanchez-Medina, Gabriela A.:
Gen Hosp Mexico Dr Eduardo Liceaga, Res Div, Mexico City 06726, DF, Mexico
Islas-Andrade, Sergio:
Gen Hosp Mexico Dr Eduardo Liceaga, Res Div, Mexico City 06726, DF, Mexico
Melendez-Mier, Guillermo:
Gen Hosp Mexico Dr Eduardo Liceaga, Res Div, Mexico City 06726, DF, Mexico
Escobedo, Galileo:
Univ Nacl Autonoma Mexico, Sch Med, Unit Expt Med, Gen Hosp Mexico Dr Eduardo Liceaga, Mexico City 06726, DF, Mexico
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