Ilex paraguariensis extracts reduce blood glucose, peripheral neuropathy and oxidative damage in male mice exposed to streptozotocin
Por:
de Lima M.E., Colpo A.Z.C., Rosa H., Salgueiro A.C.F., da Silva M.P., Noronha D.S., Santamaría A., Folmer V.
Publicada:
1 ene 2018
Resumen:
Ilex paraguariensis (IP) is used for the preparation of stimulant drinks commonly consumed in South America. Extracts of this plant are known to contain a wide variety of polyphenols, exerting beneficial effects as antioxidant. The aim of this study was to evaluate for the first time the effect of yerba mate extracts in a model of type 1 diabetes induced by streptozotocin (STZ) in mice. We evaluated extract compounds, glucose levels, serum transaminases, and fructosamine in blood, and oxidative stress parameters in liver, kidney and brain. Finally, we analyzed the thermal sensitivity as an indicator of diabetic neuropathy. Ilex paraguariensis extracts reduced hyperglycemia, normalized oxidative stress parameters and prevented peripheral neuropathy. Altogether, these effects can be attributed to the potent antioxidant capacity of IP combined with its potential hypoglycemic effect. We suggest that IP compounds may help to design therapeutic alternatives for the treatment of diabetes mellitus. © 2018
Filiaciones:
de Lima M.E.:
Universidade Federal do Pampa, Programa de Pós-Graduação em Bioquímica, Uruguaiana, RS, Brazil
Instituto Nacional de Neurología y Neurocirurgía Manuel Velasco Suárez, México, CDMX, Mexico
Colpo A.Z.C.:
Universidade Federal do Pampa, Programa de Pós-Graduação em Bioquímica, Uruguaiana, RS, Brazil
Rosa H.:
Universidade Federal do Pampa, Programa de Pós-Graduação em Bioquímica, Uruguaiana, RS, Brazil
Salgueiro A.C.F.:
Universidade Federal do Pampa, Programa de Pós-Graduação em Bioquímica, Uruguaiana, RS, Brazil
da Silva M.P.:
Universidade Federal do Pampa, Programa de Pós-Graduação em Bioquímica, Uruguaiana, RS, Brazil
Noronha D.S.:
Universidade Federal do Pampa, Programa de Pós-Graduação em Bioquímica, Uruguaiana, RS, Brazil
Santamaría A.:
Instituto Nacional de Neurología y Neurocirurgía Manuel Velasco Suárez, México, CDMX, Mexico
Folmer V.:
Universidade Federal do Pampa, Programa de Pós-Graduação em Bioquímica, Uruguaiana, RS, Brazil
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