HPV-11 variability, persistence and progression to genital warts in men: The HIM study
Por:
Flores-Díaz E., Sereday K.A., Ferreira S., Sirak B., Sobrinho J.S., Baggio M.L., Galan L., Silva R.C., Lazcano-Ponce E., Giuliano A.R., Villa L.L., Sichero L., Lin H., Messina J., Campbell C.P., Gage C., Ingles D.J., Isaacs K., Kennedy K., Bobanic A., Rahman S., Schabath M., Nyitray A., Rathwell J., Cintra R., Cernicchiaro F., Ribeiro G., Otero R., Bocalon R., Antunes J., Silva F., Terreri R., Valdez A.C., de Jesús Alvear Vásquez R., Juárez O.R., del Carmen González Sosa R., Vences R.R., Segura M.H., Galván A.R., Rodríguez P.R., Vélez A.L.L., García G.D., Abarca V.C., Quevedo G.F., del Pilar Hernández Nevárez M., Martínez G.S., Rojas A.O., Flores C.O.B.
Publicada:
1 ene 2017
Categoría:
Virology
Resumen:
HPV-11 and HPV-6 are the etiological agents of about 90% of genital warts (GWs). The intra-typic variability of HPV-11 and its association with infection persistence and GW development remains undetermined. Here, HPV infection in men (HIM) participants who had an HPV-11 genital swab and/or GW, preceded or not by a normal skin genital swab were analysed. Genomic variants were characterized by PCR-sequencing and classified within lineages (A, B) and sublineages (A1, A2, A3, A4). HPV-11 A2 variants were the most frequently detected in the genital swab samples from controls and in both genital swabs and GW samples from cases. The same HPV-11 variant was detected in the GW sample and its preceding genital swab. There was a lack of association between any particular HPV-11 variant and the increased risk for GW development. © 2017 The Authors.
Filiaciones:
Flores-Díaz E.:
Molecular Biology Laboratory, Center for Translational Research in Oncology, Instituto do Cancer do Estado de Sao Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Institute for Research in Immunology and Cancer-IRIC, Faculty of Medicine, University of Montreal, Montreal, QC, Canada
Brazil
Sereday K.A.:
Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States
United States
Ferreira S.:
Molecular Biology Laboratory, Center for Translational Research in Oncology, Instituto do Cancer do Estado de Sao Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Brazil
Sirak B.:
Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States
United States
Sobrinho J.S.:
Molecular Biology Laboratory, Center for Translational Research in Oncology, Instituto do Cancer do Estado de Sao Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Brazil
Baggio M.L.:
Molecular Biology Laboratory, Center for Translational Research in Oncology, Instituto do Cancer do Estado de Sao Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Brazil
Galan L.:
Ludwig Institute for Cancer Research, São Paulo branch, São Paulo, Brazil
Brazil
Silva R.C.:
Centro de Referência e Treinamento DST/Aids, São Paulo, Brazil
Brazil
Lazcano-Ponce E.:
Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca, Mexico
Mexico
Giuliano A.R.:
Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States
United States
Villa L.L.:
Molecular Biology Laboratory, Center for Translational Research in Oncology, Instituto do Cancer do Estado de Sao Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Department of Radiology and Oncology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
Brazil
Sichero L.:
Molecular Biology Laboratory, Center for Translational Research in Oncology, Instituto do Cancer do Estado de Sao Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Brazil
Lin H.:
United States
Messina J.:
United States
Campbell C.P.:
United States
Gage C.:
United States
Ingles D.J.:
United States
Isaacs K.:
United States
Kennedy K.:
United States
Bobanic A.:
United States
Rahman S.:
United States
Schabath M.:
United States
Nyitray A.:
United States
Rathwell J.:
United States
Cintra R.:
Brazil
Cernicchiaro F.:
Brazil
Ribeiro G.:
Brazil
Otero R.:
Brazil
Bocalon R.:
Brazil
Antunes J.:
Brazil
Silva F.:
Brazil
Terreri R.:
Brazil
Valdez A.C.:
Mexico
de Jesús Alvear Vásquez R.:
Mexico
Juárez O.R.:
Mexico
del Carmen González Sosa R.:
Mexico
Vences R.R.:
Mexico
Segura M.H.:
Mexico
Galván A.R.:
Mexico
Rodríguez P.R.:
Mexico
Vélez A.L.L.:
Mexico
García G.D.:
Mexico
Abarca V.C.:
Mexico
Quevedo G.F.:
Mexico
del Pilar Hernández Nevárez M.:
Mexico
Martínez G.S.:
Mexico
Rojas A.O.:
Mexico
Flores C.O.B.:
Mexico
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