Calcium-regulated chloride channel anoctamin-1 is present in the suprachiasmatic nuclei of rats
Por:
Aguilar-Roblero, Raul, Mejia-Lopez, Adriana, Cortes-Pedroza, Dominique, Chavez-Juarez, Jose L., Gutierrez-Monreal, Miguel A., Dominguez, Gabriela, Vergara, Paula, Segovia, Jose
Publicada:
7 mar 2018
Categoría:
Neuroscience (miscellaneous)
Resumen:
Calcium-regulated chloride channel (CaCC) anoctamin-1 has been recently identified in neurons. In neurons, which express the Na + -K + -2Cl - cotransporter, activation of CaCCs increases firing frequency, by reversion between the Cl - equilibrium potential and the membrane resting potential, leading to membrane depolarization by Cl - extrusion from the cell. Although there are no reports of CaCCs present in the suprachiasmatic nuclei (SCN), the fact that Na + -K + -2Cl - cotransporter is present in SCN neurons, where it has been shown to be involved in the excitatory effects of ?-aminobutyric acid, together with the increase of neuronal firing rate induced by release of intracellular Ca 2+ after administration of 100 nM ryanodine, leads us to determine whether CaCCs are present in the SCN. Immunohistochemistry and western blots show the expression of the CaCCs anoctamin-1 protein. Quantitative PCR demonstrated the expression of anoctamin-1 mRNA in the SCN. These results clearly indicate the presence of CaCC in SCN of rats. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
Filiaciones:
Aguilar-Roblero, Raul:
Departamento de Neurociencias Cognitivas, División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, PO Box 70-253, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Div Neurociencias, Dept Neurociencias Cognit, POB 70-253, Mexico City 04510, DF, Mexico
Mejia-Lopez, Adriana:
Departamento de Neurociencias Cognitivas, División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, PO Box 70-253, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Div Neurociencias, Dept Neurociencias Cognit, POB 70-253, Mexico City 04510, DF, Mexico
Cortes-Pedroza, Dominique:
Departamento de Neurociencias Cognitivas, División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, PO Box 70-253, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Div Neurociencias, Dept Neurociencias Cognit, POB 70-253, Mexico City 04510, DF, Mexico
Chavez-Juarez, Jose L.:
Departamento de Neurociencias Cognitivas, División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, PO Box 70-253, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Div Neurociencias, Dept Neurociencias Cognit, POB 70-253, Mexico City 04510, DF, Mexico
Gutierrez-Monreal, Miguel A.:
Departamento de Neurociencias Cognitivas, División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, PO Box 70-253, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Div Neurociencias, Dept Neurociencias Cognit, POB 70-253, Mexico City 04510, DF, Mexico
Dominguez, Gabriela:
Departamento de Neurociencias Cognitivas, División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, PO Box 70-253, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Div Neurociencias, Dept Neurociencias Cognit, POB 70-253, Mexico City 04510, DF, Mexico
Vergara, Paula:
Department of Physiology, Biophysics, and Neurosciences, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City, Mexico
Natl Polytech Inst, Ctr Res & Adv Studies, Dept Physiol Biophys & Neurosci, Mexico City, DF, Mexico
Segovia, Jose:
Department of Physiology, Biophysics, and Neurosciences, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City, Mexico
Natl Polytech Inst, Ctr Res & Adv Studies, Dept Physiol Biophys & Neurosci, Mexico City, DF, Mexico
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