Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat
Por:
Zepeda Mendoza M.L., Xiong Z., Escalera-Zamudio M., Runge A.K., Thézé J., Streicker D., Frank H.K., Loza-Rubio E., Liu S., Ryder O.A., Samaniego Castruita J.A., Katzourakis A., Pacheco G., Taboada B., Löber U., Pybus O.G., Li Y., Rojas-Anaya E., Bohmann K., Carmona Baez A., Arias C.F., Liu S., Greenwood A.D., Bertelsen M.F., White N.E., Bunce M., Zhang G., Sicheritz-Pontén T., Gilbert M.P.T.
Publicada:
1 abr 2018
Resumen:
Adaptation to specialized diets often requires modifications at both genomic and microbiome levels. We applied a hologenomic approach to the common vampire bat (Desmodus rotundus), one of the only three obligate blood-feeding (sanguivorous) mammals, to study the evolution of its complex dietary adaptation. Specifically, we assembled its high-quality reference genome (scaffold N50 = 26.9 Mb, contig N50 = 36.6 kb) and gut metagenome, and compared them against those of insectivorous, frugivorous and carnivorous bats. Our analyses showed a particular common vampire bat genomic landscape regarding integrated viral elements, a dietary and phylogenetic influence on gut microbiome taxonomic and functional profiles, and that both genetic elements harbour key traits related to the nutritional (for example, vitamin and lipid shortage) and non-nutritional (for example, nitrogen waste and osmotic homeostasis) challenges of sanguivory. These findings highlight the value of a holistic study of both the host and its microbiota when attempting to decipher adaptations underlying radical dietary lifestyles. © 2018 The Author(s).
Filiaciones:
Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
China National GeneBank, BGI-Shenzhen, Shenzhen, China
Department of Wildlife Diseases, Leibniz Institute for Zoo and Wildlife Research (IZW), Berlin, Germany
Department of Zoology, University of Oxford, Oxford, United Kingdom
Institute of Biodiversity, Animal Health and Comparative Medicine & MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom
Department of Biology, Stanford University, Stanford, CA, United States
Centro Nacional de Investigación Disciplinaria en Microbiología Animal-INIFAP, Ciudad de México, Mexico
San Diego Zoo Institute for Conservation Research, Escondido, CA, United States
Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Mexico
Undergraduate Program for Genomic Sciences, Center for Genomic Sciences, National Autonomous University of Mexico, Cuernavaca, Mexico
Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany
Center for Zoo and Wild Animal Health, Copenhagen Zoo, Frederiksberg, Denmark
Australian Wildlife Forensic Services, Department of Environment and Agriculture, Curtin University, Perth, Australia
Trace and Environmental DNA Laboratory, Department of Environment and Agriculture, Curtin University, Perth, Australia
Centre for Social Evolution, Department of Biology, University of Copenhagen, Copenhagen, Denmark
Center for Biological Sequence Analysis, Department of Bio and Health Informatics, Technical University of Denmark, Kongens Lyngby, Denmark
Norwegian University of Science and Technology, University Museum, Trondheim, Norway
|