Molecular epidemiology of Mycobacterium tuberculosis in Baja California, Mexico: A result of human migration?
Por:
Flores-Lopez, Carlos A., Zenteno-Cuevas, Roberto, Laniado-Laborin, Rafael, Reynaud, Yann, Alejandra Garcia-Ortiz, Rosa, Gonzalez-Y-Merchand, Jorge A., Rivera, Sandra, Vazquez-Chacon, Carlos A., Vaughan, Gilberto, Armando Martinez-Guarneros, Jose, Lorena Victoria-Cota, Nelva, Cruz-Rivera, Mayra, Rastogi, Nalin, Muniz-Salazar, Raquel
Publicada:
1 nov 2017
Resumen:
The State of Baja California (BC) exhibits the highest incidence and prevalence rates of tuberculosis (TB), and multidrug-resistant TB (MDR-TB) in Mexico. However information about the circulation of M. tuberculosis lineages in BC and Mexico as a whole is limited. Here, we describe the genetic relationship and genetic diversity among M. tuberculosis clinical isolates (n = 140) collected in BC between October 2009 and April 2011 with other regions of Mexico, the United States, and Latin America. All specimens were genotyped based on 24 mycobacterial interspersed repetitive units (MIRU)-variable number of tandem repeats (VNTR) loci. Population structure and minimum spanning tree (MST) analyses were used to assess the genetic diversity and distribution of BC isolates in comparison to USA and South America strains. Among the nine lineages observed, LAM, Haarlem and S were the most frequent identified in BC. Population structure analysis clustered most BC isolates (41%) into three distinctive groups that included strains from San Diego and South America, whereas other BC strains (22%) clustered with other Mexican strains. A subset of isolates (12%) seemed to be autochthonous of BC, while 25% were cosmopolitan and grouped into multiple clusters. It is highly likely that the TB genetic structure observed in BC is due to human migration. Additional studies are required to determine the mechanism involved in the phylogeographic distribution of M. tuberculosis in Mexico. Implementation of domestic molecular TB surveillance programs is required to better understand the molecular epidemiology of TB not only in the region but at the national level. © 2016 Elsevier B.V.
Filiaciones:
Flores-Lopez, Carlos A.:
Univ Autonoma Baja California, Fac Ciencias, Ensenada, Baja California, Mexico
Red Multidisciplinaria Invest TB, Ensenada, Baja California, Mexico
Zenteno-Cuevas, Roberto:
Univ Veracruzana, Inst Salud Publ, Xalapa, Veracruz, Mexico
Red Multidisciplinaria Invest TB, Ensenada, Baja California, Mexico
Laniado-Laborin, Rafael:
Hosp Gen Tijuana, Clin TB, ISESALUD, Tijuana, Baja California, Mexico
Red Multidisciplinaria Invest TB, Ensenada, Baja California, Mexico
Reynaud, Yann:
WHO, Inst Pasteur Guadeloupe, Supranat TB Reference Lab, Abymes, France
Alejandra Garcia-Ortiz, Rosa:
Univ Autonoma Baja California, Escuela Ciencias Salud, Lab Epidemiol & Ecol Mol, Ensenada, Baja California, Mexico
Gonzalez-Y-Merchand, Jorge A.:
Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Mexico City, DF, Mexico
Red Multidisciplinaria Invest TB, Ensenada, Baja California, Mexico
Rivera, Sandra:
Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Mexico City, DF, Mexico
Red Multidisciplinaria Invest TB, Ensenada, Baja California, Mexico
Vazquez-Chacon, Carlos A.:
Inst Diagnost & Referencia Epidemiol, Mexico City, DF, Mexico
Vaughan, Gilberto:
Inst Diagnost & Referencia Epidemiol, Mexico City, DF, Mexico
Armando Martinez-Guarneros, Jose:
Inst Diagnost & Referencia Epidemiol, Mexico City, DF, Mexico
Red Multidisciplinaria Invest TB, Ensenada, Baja California, Mexico
Lorena Victoria-Cota, Nelva:
Univ Autonoma Baja California, Escuela Ciencias Salud, Lab Epidemiol & Ecol Mol, Ensenada, Baja California, Mexico
Cruz-Rivera, Mayra:
Univ Nacl Autonoma Mexico, Mexico City, DF, Mexico
Rastogi, Nalin:
WHO, Inst Pasteur Guadeloupe, Supranat TB Reference Lab, Abymes, France
Muniz-Salazar, Raquel:
Univ Autonoma Baja California, Escuela Ciencias Salud, Lab Epidemiol & Ecol Mol, Ensenada, Baja California, Mexico
Red Multidisciplinaria Invest TB, Ensenada, Baja California, Mexico
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