Peripheral oxytocin receptors inhibit the nociceptive input signal to spinal dorsal horn wide-dynamic-range neurons
Por:
Gonzalez-Hernandez, Abimael, Manzano-Garcia, Alfredo, Martinez-Lorenzana, Guadalupe, Tello-Garcia, Irma A., Carranza, Martha, Aramburo, Carlos, Condes-Lara, Miguel
Publicada:
1 nov 2017
Resumen:
Oxytocin (OT) has emerged as a mediator of endogenous analgesia in behavioral and electrophysiological experiments. In fact, OT receptors (OTRs) in the spinal dorsal horn participate in a selective inhibition of the neuronal activity mediated by Ad and C fibers but not Aß fibers. This study shows that OTRs are expressed in the terminal nerve endings and are able to inhibit nociceptive neuronal firing. Indeed, local peripheral OT blocked the first sensorial activity of Ad and C fibers recorded in the spinal cord neurons. Furthermore, using the formalin behavioral nociceptive test, we demonstrated that only ipsilateral OTR activation inhibits pain behavior. Our data are reinforced by the fact that the OTR protein is expressed in the sciatic nerve. Consistent with this, immunofluorescence of primary afferent fibers suggest that OTRs could be located in nociceptive-specific terminals of the skin. Taken together, our results suggest that OTRs could be found in nociceptive terminals and that on activation they are able to inhibit nociceptive input. © 2017 International Association for the Study of Pain.
Filiaciones:
Gonzalez-Hernandez, Abimael:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Neurobiol Desarrollo & Neurofisiol, Campus UNAM Juriquilla, Queretaro 76230, Mexico
Manzano-Garcia, Alfredo:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Neurobiol Desarrollo & Neurofisiol, Campus UNAM Juriquilla, Queretaro 76230, Mexico
Martinez-Lorenzana, Guadalupe:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Neurobiol Desarrollo & Neurofisiol, Campus UNAM Juriquilla, Queretaro 76230, Mexico
Tello-Garcia, Irma A.:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Neurobiol Desarrollo & Neurofisiol, Campus UNAM Juriquilla, Queretaro 76230, Mexico
Carranza, Martha:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Neurobiol Celular & Mol, Campus UNAM Juriquilla, Queretaro, Mexico
Aramburo, Carlos:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Neurobiol Celular & Mol, Campus UNAM Juriquilla, Queretaro, Mexico
Condes-Lara, Miguel:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Neurobiol Desarrollo & Neurofisiol, Campus UNAM Juriquilla, Queretaro 76230, Mexico
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