Gender Differences in the Acute Kidney Injury to Chronic Kidney Disease Transition
Por:
Lima-Posada, Ixchel, Portas-Cortes, Cinthya, Perez-Villalva, Rosalba, Fontana, Francesco, Rodriguez-Romo, Roxana, Prieto, Rodrigo, Sanchez-Navarro, Andrea, Rodriguez-Gonzalez, Guadalupe L., Gamba, Gerardo, Zambrano, Elena, Bobadilla, Norma A.
Publicada:
25 sep 2017
Categoría:
Multidisciplinary
Resumen:
This study evaluated if there is a sexual dimorphism in the acute kidney
injury (AKI) to chronic kidney disease (CKD) transition and the
time-course of the potential mechanisms involved in the dimorphic
response. Female and male rats were divided into sham-operated or
underwent 45-min renal ischemia (F + IR, and M + IR). All groups were
studied at 24-h and 1, 2, 3, or 4-months post-ischemia. Additionally,
oophorectomized rats were divided into sham or IR groups. After 24-h,
AKI extent was simllar in females and males, but female rats exhibited
less oxidative stress and increased renal GSH content. After 4-months
and despite similar AKI, the M + IR group developed CKD characterized by
proteinuria, tubulointerstitial fibrosis, glomerular hypertrophy,
increased oxidative stress and a reduction in HIF1 alpha and VEGF from
the 1st-month and persisting throughout the time-course studied.
Interestingly, the F + IR group did not develop CKD due to lesser
oxidative stress and increased eNOS, TGF beta and HIF1 alpha mRNA levels
from the 1st-month after IR. Whereas, oophorectomized rats did develop
CKD. We found a sexual dimorphic response in the AKI to CKD transition.
Early antioxidant defense and higher TGF beta, HIF1a and eNOS were among
the renoprotective mechanisms that the F + IR group demonstrated.
Filiaciones:
Lima-Posada, Ixchel:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mol Physiol Unit, Mexico City, DF, Mexico
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nephrol, Mexico City, DF, Mexico
Portas-Cortes, Cinthya:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mol Physiol Unit, Mexico City, DF, Mexico
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nephrol, Mexico City, DF, Mexico
Perez-Villalva, Rosalba:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mol Physiol Unit, Mexico City, DF, Mexico
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nephrol, Mexico City, DF, Mexico
Fontana, Francesco:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mol Physiol Unit, Mexico City, DF, Mexico
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nephrol, Mexico City, DF, Mexico
Rodriguez-Romo, Roxana:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mol Physiol Unit, Mexico City, DF, Mexico
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nephrol, Mexico City, DF, Mexico
Prieto, Rodrigo:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mol Physiol Unit, Mexico City, DF, Mexico
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nephrol, Mexico City, DF, Mexico
Sanchez-Navarro, Andrea:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mol Physiol Unit, Mexico City, DF, Mexico
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nephrol, Mexico City, DF, Mexico
Rodriguez-Gonzalez, Guadalupe L.:
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Mexico City, DF, Mexico
Gamba, Gerardo:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mol Physiol Unit, Mexico City, DF, Mexico
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nephrol, Mexico City, DF, Mexico
Zambrano, Elena:
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Mexico City, DF, Mexico
Bobadilla, Norma A.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mol Physiol Unit, Mexico City, DF, Mexico
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nephrol, Mexico City, DF, Mexico
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