Pathophysiological signatures of functional connectomics in parkinsonian and dyskinetic striatal microcircuits
Por:
Perez-Ortega, Jesus, Duhne, Mariana, Lara-Gonzalez, Esther, Plata, Victor, Gasca, Deisy, Galarraga, Elvira, Hernandez-Cruz, Arturo, Bargas, Jose
Publicada:
1 jul 2016
Categoría:
Neurology
Resumen:
A challenge in neuroscience is to integrate the cellular and system
levels. For instance, we still do not know how a few dozen neurons
organize their activity and relations in a microcircuit or module of
histological scale. By using network theory and Ca2+ imaging with
single-neuron resolution we studied the way in which striatal
microcircuits of dozens of cells orchestrate their activity. In
addition, control and diseased striatal tissues were compared in rats.
In the control tissue, functional connectomics revealed small-world,
scale-free and hierarchical network properties. These properties were
lost during pathological conditions in ways that could be quantitatively
analyzed. Decorticated striatal circuits disclosed that corticostriatal
interactions depend on privileged connections with a set of highly
connected neurons or ``hubs''. In the 6-OHDA model of Parkinson's
disease there was a decrease in hubs number; but the ones that remained
were linked to dominant network states. L-DOPA induced dyskinesia
provoked a loss in the hierarchical structure of the circuit. All these
conditions conferred distinct temporal sequences to circuit activity.
Temporal sequences appeared as particular signatures of disease process
thus bringing the possibility of a future quantitative pathophysiology
at a histological scale. (C) 2016 Elsevier Inc All rights reserved.
Filiaciones:
Perez-Ortega, Jesus:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Div Neurociencias, Circuito Ext S-N, Mexico City 04510, DF, Mexico
Duhne, Mariana:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Div Neurociencias, Circuito Ext S-N, Mexico City 04510, DF, Mexico
Lara-Gonzalez, Esther:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Div Neurociencias, Circuito Ext S-N, Mexico City 04510, DF, Mexico
Plata, Victor:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Div Neurociencias, Circuito Ext S-N, Mexico City 04510, DF, Mexico
Gasca, Deisy:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Juriquilla, Queretaro, Mexico
Galarraga, Elvira:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Div Neurociencias, Circuito Ext S-N, Mexico City 04510, DF, Mexico
Hernandez-Cruz, Arturo:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Div Neurociencias, Circuito Ext S-N, Mexico City 04510, DF, Mexico
Bargas, Jose:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Div Neurociencias, Circuito Ext S-N, Mexico City 04510, DF, Mexico
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