High prevalence of multidrug-resistant Escherichia coli isolates from children with and without diarrhoea and their susceptibility to the antibacterial activity of extracts/fractions of fruits native to Mexico
Por:
de Jesus Uribe-Beltran, Magdalena, Patricia Ahumada-Santos, Yesmi, Paz Diaz-Camacho, Sylvia, Alberto Eslava-Campos, Carlos, Ernesto Reyes-Valenzuela, Jesus, Elena Baez-Flores, Maria, Osuna-Ramirez, Ignacio, Delgado-Vargas, Francisco
Publicada:
1 jul 2017
Resumen:
Purpose. This paper aims to evaluate the antimicrobial resistance of
Esherichia coli isolates from children under 5 years old, with and
without diarrhoea, who were hospital outpatients in Culiacan, Sinaloa,
Mexico. It also looks at the antimicrobial activity of fruit extracts
against selected multidrug-resistant (MDR) E. coli strains.
Methodology. A total of 205 E. coli isolates from stool samples were
collected from 94 children under 5 years old who were outpatients from
two hospitals in the city of Culiacan, Sinaloa, Mexico, during the
autumn/winter of 2003/04; their resistance profiles to 19 commercial
antimicrobials were investigated using the Kirby-Bauer method. The
antibacterial activities of extracts/fractions of fruits (i.e. uvalama,
Vitex mollis; ayale, Crescentia alata; and arrayan, Psidium sartorianum)
were evaluated using the broth microdilution method.
Results. All E. coli isolates were susceptible to amikacin,
nitrofurantoin and meropenem, and approximately 96% were resistant to
at least one antimicrobial, especially carbenicillin (93.2 %),
cefuroxime sodium (53.7 %), ampicillin (40 %) and
trimethoprim/sulfamethoxazole (35.1 %). Likewise, the frequency of MDR
strains (44.9 %) was high, and no significant association with
diarrhoea symptoms was found. Remarkably, all fruit extracts/fractions
showed antibacterial activity against some, but not all, MDR isolates.
The lowest minimal inhibitory concentration values were for the hexane
fraction of arrayan (0.25 mg ml(-1)).
Conclusion. A high number of antimicrobial-resistant E. coli (especially
to beta-lactams and sulfonamides) and MDR isolates were detected in
children under 5 years old, irrespective of diarrhoea symptoms; this is
novel information for Culiacan, Sinaloa, Mexico. Moreover, our results
showed that the studied fruit extracts/fractions are potential
alternative or complementary treatments for MDR E. coli strains.
Filiaciones:
de Jesus Uribe-Beltran, Magdalena:
Autonomous Univ Sinaloa, Sch Chem & Biol Sci, Ciudad Univ, Culiacan, Sinaloa, Mexico
Patricia Ahumada-Santos, Yesmi:
Autonomous Univ Sinaloa, Sch Chem & Biol Sci, Ciudad Univ, Culiacan, Sinaloa, Mexico
Paz Diaz-Camacho, Sylvia:
Autonomous Univ Sinaloa, Sch Chem & Biol Sci, Ciudad Univ, Culiacan, Sinaloa, Mexico
Alberto Eslava-Campos, Carlos:
Univ Nacl Autonoma Mexico, Sch Med, Ciudad Univ, Mexico City 04510, DF, Mexico
Hosp Infantil de Mexico Federico Gomez, Hemato Oncol & Res Unit, Lab Bacterial Pathogen, Mexico City 06720, DF, Mexico
Ernesto Reyes-Valenzuela, Jesus:
Autonomous Univ Sinaloa, Sch Chem & Biol Sci, Ciudad Univ, Culiacan, Sinaloa, Mexico
Elena Baez-Flores, Maria:
Autonomous Univ Sinaloa, Sch Chem & Biol Sci, Ciudad Univ, Culiacan, Sinaloa, Mexico
Osuna-Ramirez, Ignacio:
Autonomous Univ Sinaloa, Sch Chem & Biol Sci, Ciudad Univ, Culiacan, Sinaloa, Mexico
Delgado-Vargas, Francisco:
Autonomous Univ Sinaloa, Sch Chem & Biol Sci, Ciudad Univ, Culiacan, Sinaloa, Mexico
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