Genetic Diversity and Differentiation in Urban and Indigenous Populations of Mexico: Patterns of Mitochondrial DNA and Y-Chromosome Lineages
Por:
Gonzalez-Sobrino, Blanca Z., Pintado-Cortina, Ana P., Sebastian-Medina, Leticia, Morales-Mandujano, Fabiola, Contreras, Alejandra V., Aguilar, Yasnaya E., Chavez-Benavides, Juan, Carrillo-Rodriguez, Aurelio, Silva-Zolezzi, Irma, Medrano-Gonzalez, Luis
Publicada:
2 ene 2016
Resumen:
Aside from the admixture between indigenous people and people from overseas, populations in Mexico changed drastically after the Spanish conquest of the sixteenth century, forming an intricate history that has been underutilized in understanding the genetic population structure of Mexicans. To infer historical processes of isolation, dispersal, and assimilation, we examined the phylogeography of mitochondrial (mt) DNA and Y-chromosome lineages in 3,026 individuals from 10 urban and nine indigenous populations by identifying single nucleotide polymorphisms. A geographic array with a predominance of Amerindian lineages was observed for mtDNA, with northern indigenous populations being divergent from the central and southern indigenous populations; urban populations showed low differentiation with isolation by distance. Y-chromosome variation distinguished urban and indigenous populations through the Amerindian haplogroup Q frequency. The MtDNA and the Y-chromosome together primarily distinguished urban and indigenous populations, with different geographic arrays for both. Gene flow across geographical distance and between the urban and indigenous realms appears to have altered the pre-Hispanic phylogeography in central and southern Mexico, mainly by displacement of women, while maintaining the indigenous isolation in the north, southeast, and Zapotec regions. Most Amerindian mtDNA diversity currently occurs in urban populations and appears to be reduced among indigenous people. © Copyright 2016 Society for Biodemography and Social Biology.
Filiaciones:
Gonzalez-Sobrino, Blanca Z.:
Univ Nacl Autonoma Mexico, Lab Antropol Genet, Inst Invest Antropol, Mexico City 04510, DF, Mexico
Pintado-Cortina, Ana P.:
Inst Nacl Antropol Hist, Direcc Etnol & Antropol Social, Mexico City, DF, Mexico
Sebastian-Medina, Leticia:
Inst Nacl Med Genom, Lab Nutrigenet & Nutrigen, Mexico City, DF, Mexico
Morales-Mandujano, Fabiola:
Inst Nacl Med Genom, Lab Nutrigenet & Nutrigen, Mexico City, DF, Mexico
Contreras, Alejandra V.:
Inst Nacl Med Genom, Lab Nutrigenet & Nutrigen, Mexico City, DF, Mexico
Aguilar, Yasnaya E.:
Univ Nacl Autonoma Mexico, Posgrado Antropol, Fac Filosofia & Letras, Mexico City 04510, DF, Mexico
Chavez-Benavides, Juan:
Inst Mexicano Seguro Social, Coordinac Estatal Chihuahua Programa Oportunidade, Chihuahua, Mexico
Carrillo-Rodriguez, Aurelio:
Serv Salud Nayarit, Dept Epidemiol, Tepic, Mexico
Silva-Zolezzi, Irma:
Inst Nacl Med Genom, Lab Nutrigenet & Nutrigen, Mexico City, DF, Mexico
Nestec Ltd, Nestle Res Ctr, Nutr & Hlth Dept, Vers Chez Les Blanc, CH-1000 Lausanne, Switzerland
Medrano-Gonzalez, Luis:
Univ Nacl Autonoma Mexico, Dept Evolut Biol, Fac Ciencias, Av Univ 3000, Mexico City 04510, DF, Mexico
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