Protective effects of S-allyl cysteine on behavioral, morphological and biochemical alterations in rats subjected to chronic restraint stress: Antioxidant and anxiolytic effects
Por:
Becerril-Chavez, Hugo, Laura Colin-Gonzalez, Ana, Villeda-Hernandez, Juana, Galvan-Arzate, Sonia, Chavarria, Anahi, Eduarda de Lima, Maria, Tunez, Isaac, Santamaria, Abel
Publicada:
1 ago 2017
Resumen:
S-allyl cysteine (SAC) is a garlic-derived compound with antioxidant
properties. Restraint stress constitutes a rodent model mimicking
different features of human stress. The effects of SAC on behavioral,
biochemical and morphological endpoints of brain alterations induced by
chronic restraint stress were evaluated in rats. Restraint stress
sessions were performed every day for 6 h during 21 consecutive days.
SAC (100 mg/kg, i.p.) was administered daily 30 min before every single
stress session. Behavioral tests comprised anxiety-like and
depression-like challenges. Biochemical and morphological endpoints were
estimated in three brain regions: striatum, hippocampus and cortex.
Stressed animals exhibited augmented anxiety-like behavior, depression
and morphological alterations, and these changes were accompanied by
increased oxidative damage, compensatory regulation of antioxidant
enzymes, and increased corticosterone plasma levels. SAC prevented
anxiety-like behavior elicited by chronic stress in rats, and reduced
morphological and biochemical alterations. The protective actions of SAC
are related to its antioxidant properties. (C) 2017 Elsevier Ltd. All
rights reserved.
Filiaciones:
Becerril-Chavez, Hugo:
Inst Nacl Neurol & Neurocirug, Lab Aminoacidos Excitadores, Insurgentes Sur 3877, Mexico City 14269, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Ciencias, Insurgentes Sur 3000, Mexico City 04510, DF, Mexico
Laura Colin-Gonzalez, Ana:
Inst Nacl Neurol & Neurocirug, Lab Aminoacidos Excitadores, Insurgentes Sur 3877, Mexico City 14269, DF, Mexico
Villeda-Hernandez, Juana:
Inst Nacl Neurol & Neurocirug, Lab Patol Expt, Insurgentes Sur 3877, Mexico City 14269, DF, Mexico
Galvan-Arzate, Sonia:
Inst Nacl Neurol & Neurocirug, Dept Neuroquim, Insurgentes Sur 3877, Mexico City 14269, DF, Mexico
Chavarria, Anahi:
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Insurgentes Sur 3000, Mexico City 06726, DF, Mexico
Eduarda de Lima, Maria:
Inst Nacl Neurol & Neurocirug, Lab Aminoacidos Excitadores, Insurgentes Sur 3877, Mexico City 14269, DF, Mexico
Univ Fed Pampa, Campus Uruguaiana,BR 472, BR-97508000 Bage, RS, Brazil
Tunez, Isaac:
Univ Cordoba, Inst Maimonides Invest Biomed Cordoba IMIBIC, Fac Med & Enfermeria, Dept Bioquim & Biol Mol, E-14071 Cordoba, Spain
Santamaria, Abel:
Inst Nacl Neurol & Neurocirug, Lab Aminoacidos Excitadores, Insurgentes Sur 3877, Mexico City 14269, DF, Mexico
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