The Effect of Gabapentin and Tramadol in Cancer Pain Induced by Glioma Cell in Rat Femur
Por:
Corona-Ramos J.N., Déciga-Campos M., Romero-Piña M., Medina L.A., Martínez-Racine I., Jaramillo-Morales O.A., García-López P., López-Muñoz F.J.
Publicada:
1 ago 2017
Categoría:
Drug discovery
Resumen:
The presence of pain as part of the cancer process is variable.
Glioblastoma multiform (GBM) can produce bone metastasis, a condition
that involves other pathological phenotypes including neuropathic and
inflammatory pain. Tramadol and gabapentin are drugs used in the
treatment of neuropathic pain. However, there are no studies evaluating
their analgesic effects in bone metastasis. We produced a pain model
induced by the inoculation of glioma cells (10(5)) into the rat femur,
by perforating the intercodiloid fossa. Painful behavior was evaluated
by measuring mechanical allodynia using the Von Frey test while thermal
hyperalgesia was assessed in the plantar test. Histopathological
features were evaluated and antinociceptive responses were compared
using tramadol and gabapentin. The inoculation of cells inside the right
femur produced nociceptive behaviors. Tramadol and gabapentin produced
an anti-allodynic effect in this condition, but tramadol did not produce
an anti-hyperalgesic response. The development of this model will allow
us to perform tests to elucidate the pathology of bone metastasis,
cancer pain, and in particular the pain produced by glioma. Drug Dev Res
78 : 173-183, 2017. (c) 2017 Wiley Periodicals, Inc.
Filiaciones:
Corona-Ramos J.N.:
Departamento de Farmacobiología, Cinvestav-Sede Sur, C.P. 14330, Delegación TlálpanD.F, Mexico
Déciga-Campos M.:
Sección de Estudios de Posgrado e Investigación de la Escuela Superior de Medicina del IPN, C.P. 11340D.F, Mexico
Romero-Piña M.:
Departamento de Imagenología, Instituto Nacional de Cancerología, C.P. 14080D.F, Mexico
Medina L.A.:
Instituto de Física, Universidad Nacional Autónoma de México/Unidad de Investigación Biomédica en Cáncer INCan-UNAM, C.P. 14080D.F., Mexico
Martínez-Racine I.:
Departamento de Patología, Facultad de Medicina Veterinaria y Zootecnia, UNAM, Ciudad de México04510, Mexico
Jaramillo-Morales O.A.:
Departamento de Farmacobiología, Cinvestav-Sede Sur, C.P. 14330, Delegación TlálpanD.F, Mexico
García-López P.:
Laboratorio de Farmacología, Subdirección de Investigación Básica, Instituto Nacional de Cancerología, C.P. 14080D.F, Mexico
López-Muñoz F.J.:
Departamento de Farmacobiología, Cinvestav-Sede Sur, C.P. 14330, Delegación TlálpanD.F, Mexico
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