Non-mammalian models reveal the role of alternative ligands for thyroid hormone receptors
Por:
Orozco, A., Lazcano, I., Hernández-Puga, G., Olvera, A.
Publicada:
25 dic 2017
Resumen:
Thyroid hormones, or THs, are well-known regulators of a wide range of
biological processes that occur throughout the lifespan of all
vertebrates. THs act through genomic mechanisms mediated by thyroid
hormone receptors (TRs). The main product of the thyroid gland is
thyroxine or T4, which can be further transformed by different
biochemical pathways to produce at least 15 active or inactive
molecules. T3, a product of T4 outer-ring deiodination, has been
recognized as the main bioactive TH. However, growing evidence has shown
that other TH derivatives are able to bind to, and/or activate TRs, to
induce thyromimetic effects. The compiled data in this review points to
at least two of these TR alternative ligands: TRIAC and 12. Taking this
into account, non-mammalian models have proven to be advantageous to
explore new TH derivatives with potential novel actions, prompting a
re-evaluation of the role and mechanism of action of TR alternative
ligands that were previously believed to be inactive. The functional
implications of these ligands across different vertebrates may require
us to reconsider current established notions of thyroid physiology. (C)
2017 Elsevier B.V. All rights reserved.
Filiaciones:
Orozco, A.:
Instituto de Neurobiología, Departamento de Neurobiología Celular y Molecular, Universidad Nacional Autónoma de México (UNAM), Boulevard Juriquilla 3001, Querétaro, Qro.76230, Mexico
Lazcano, I.:
Instituto de Neurobiología, Departamento de Neurobiología Celular y Molecular, Universidad Nacional Autónoma de México (UNAM), Boulevard Juriquilla 3001, Querétaro, Qro.76230, Mexico
Hernández-Puga, G.:
Instituto de Neurobiología, Departamento de Neurobiología Celular y Molecular, Universidad Nacional Autónoma de México (UNAM), Boulevard Juriquilla 3001, Querétaro, Qro.76230, Mexico
Olvera, A.:
Instituto de Neurobiología, Departamento de Neurobiología Celular y Molecular, Universidad Nacional Autónoma de México (UNAM), Boulevard Juriquilla 3001, Querétaro, Qro.76230, Mexico
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