Transforming growth factor beta and platelets in allergic rhinitis and sinusitis
Por:
Rosas A., Valencia M.P., Sánchez M., Bautista M., Rico G., Vega Robledo G.B.
Publicada:
1 ene 2011
Categoría:
Immunology and Allergy
Resumen:
Objective: To determine the TGF-? concentration in plasma and platelets in patients with allergic rhinitis or rhinosinusitis. Methods: The study group included 36 adult females, 6 with clinical and laboratory diagnoses of allergic rhinitis, 18 with allergic rhinitis and sinusitis (rhino-sinusitis) and 12 clinically healthy controls. The samples were obtained from venous blood. TGF-? was measured in plasma and in the supernatant fluid of platelets by a solid phase Enzymo-immun assay, and IL-11 was quantified using a commercial enzyme-linked im munosorbent assay kit. Results: In both patient groups platelet numbers (10 6/mL) were greater than in controls. Plasma concentration (pg/ml) of TGF-? in the allergic rhinitis group (276 ± 16) was lower than in control group (932 ± 99) (p <0.005), whereas in patients with rhino-sinusitis was higher (2606 ± 612) (p <0.005). In both patients groups, the intra-platelet TGF-? concentration was smaller than in control, but only significant (p <0.005), in allergic rhinitis patients. However, in all groups, an inverse correlation (p <0.0001) was found between the platelet number and intraplatelet TGF-? levels. Conclusions: The inverse correlation between intra-platelet TGF-? and circulating platelets number found in all individuals studied suggests that platelets do not alter the regulating mechanism of TGF-? production in allergy or infection. © 2011 Colegio Mexicano de Inmunología Clínica y Alergia, AC y de la Sociedad Latinoamericana de Alergia, Asma e Inmunología. Publicado por Elsevier México.
Filiaciones:
Servicio de Inmunología Y Alergia, Hospital General de México, Mexico
División de Invesugación, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico
Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico
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