Long term memory retrieval deficits of learned taste aversions are ameliorated by cortical fetal brain implants
Por:
Ormsby C.E., Ramírez-Amaya V., Bermúdez-Rattoni F.
Publicada:
1 ene 1998
Resumen:
In this study, the effects that fetal brain implants have on the ability to retrieve the memory for a previously acquired conditioned taste aversion (CTA) in insular cortex (IC) lesioned rats were tested. Several groups of rats were trained for a CTA, were lesioned in the IC 4 days later, were implanted with different fetal cortical tissues, were treated or untreated with nerve growth factor (NGF), and then were tested for recall either 15 or 45 days later. Rats were then retrained and tested with a different taste and in the inhibitory avoidance (IA) task. All implanted animals recovered the retrieval of CTAs learned before IC lesions; however, only the homotopic IC implants at 45 days or NGF supplemented at 15 days induced recovery of the ability to learn CTA. The latter effect was also true for IA learning. The results suggest that the brain mechanisms for recovery of memory functions are different from those of learning abilities.
Filiaciones:
Bermúdez-Rattoni F.:
Departamento de Neurocieneias, Inst. de Fisiología Celular, Univ. Nac. Auton. de México, Apartado postal 70-253, 04510 México D. F., Mexico
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