Acute toxicity of guaiacol administered subcutaneously in the mouse
Por:
Martínez Enriquez M.E., Del Villar A., Chauvet D., Lopez Valle A., Susano Pompeyo M., Campos Sepúlveda A.E.
Publicada:
1 ene 2009
Categoría:
Pharmacology
Resumen:
Guaiacol is a compound used as expectorant. In Mexico City, this product is being illegally used for aesthetic treatment with fatal results. The aim of this study is to confirm the lethal toxicity documented in humans. Male Swiss Webster mice (CFW) 30-45g were employed. Dose-response curves to guaiacol were performed by subcutaneous administration (6.25-400 ?l/40g). Basal temperature was recorded 30-120 min following administration of guaiacol. Animals were continuously observed for 120 min after guaiacol administration, lethality and toxicity manifestations were recorded. Depending of the dose, high toxicity was observed; sub lethal doses (6.25-12.5 ?l/40 g) produced tachycardia and hyperactivity, follow by sedation, hypnosis, high hypothermic effect (loss of 6° C) dyspnea, myoclonus, hematuria, blindness, abdominal distension and in higher doses (25-400 ?l/40 g) lethal effect. Necropsy showed hepatic and renal necrosis, pulmonary edema, hemorrhages and bladder clotting. We concluded that guaiacol is an extremely toxic product (toxic rating class 5) whose use should be restricted or banned.
Filiaciones:
Martínez Enriquez M.E.:
Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de Mexico, Mexico
Del Villar A.:
Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de Mexico, Mexico
Chauvet D.:
Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de Mexico, Mexico
Lopez Valle A.:
Servicio Médico Forense del Tribunal de Justicia del DF, Mexico
Susano Pompeyo M.:
Servicio Médico Forense del Tribunal de Justicia del DF, Mexico
Campos Sepúlveda A.E.:
Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de Mexico, Mexico
|