1H, 13C and 15N resonance assignment of 6aJL2(R25G), a highly fibrillogenic ?VI light chain variable domain
Por:
Gutiérrez-González L.H., Muresanu L., Del Pozo-Yauner L., Sánchez R., Guereca L., Becerril B., Lücke C.
Publicada:
1 ene 2007
Resumen:
An allotypic variation at position 25 influences the fibrillogenicity of kVI light chains, which are related to humoral immune response and have been associated with AL amyloidosis. The full resonance assignment and a preliminary structural characterization of 6aJL2(R25G) are reported. © Springer Science+Business Media B.V. 2007.
Filiaciones:
Laboratorio de Ingeniería Genética y Metabolitos Secundarios, Departamento de Biotecnología, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico
Max Planck Research Unit, Enzymology of Protein Folding, Weinbergweg 22, 06120 Halle (Saale), Germany
Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca 62210, Mexico
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