Comparison of short-term treatment regimen of ciprofloxacin versus long-term treatment regimens of trimethoprim/sulfamethoxazole or norfloxacin for uncomplicated lower urinary tract infections: A randomized, multicentre, open-label, prospect
Por:
Arredondo-García J.L., Figueroa-Damián R., Rosas A., Jáuregui A., Corral M., Costa A., Merlos R.M., Ríos-Fabra A., Amábile-Cuevas C.F., Hernández-Oliva G.M., Olguín J., Cardeñosa-Guerra O., Leal del Rosal P., Leal del Rosal J.A., Urbina Rodríguez R.E., Jaspersen Gastelum J., Valle Gay A., Leal M., Aguirre Chávez L., Ortega Rosas R., Akle D., Torres y Gutiérrez Rubio A., Orrantia Gradín R., Ceja Rodríguez J.J., Lara Pérez Soto C., Hurley D., Sotres D., Ponce de Leon R., León I., Villanueva R., Manrique J.J., Erdmenger C., Hidalgo Portillo E., Solano J.D., Mendoza Roncancio J.C., Castañeda J.R., Santos B.M., Jaramillo-Tobón A.C., Cornejo Proaño F., Paz y Miño N., Castellanos F., Gallegos B., Marcano M., Arocha I.
Publicada:
1 ene 2004
Resumen:
Objective: To compare the bacteriological and clinical efficacy of three treatments for uncomplicated cystitis in ambulatory pre-menopausal women: ciprofloxacin 250 mg orally twice daily for 3 days, trimethoprim/sulfamethoxazole 160/800 mg orally twice daily for 7 days, and norfloxacin 400 mg orally twice daily for 7 days. Materials and methods: A total of 455 women were randomly assigned to three treatment groups: 151 received ciprofloxacin, 150 received trimethoprim/sulfamethoxazole, and 154 received norfloxacin. Bacteriological cure and clinical resolution were evaluated 5-9 days and 4-6 weeks after completion of treatment. Results: There was no significant difference among the three treatment groups: overall efficacy ranged from 78.5% for the trimethoprim/sulfamethoxazole group, to 84.5% for the ciprofloxacin group. The highest overall incidence of drug-related adverse effects occurred in the trimethoprim/sulfamethoxazole patients. Conclusions: These data indicate that a 3 day treatment with ciprofloxacin is at least as clinically and bacteriologically effective as 7 day treatments with trimethoprim/sulfamethoxazole and norfloxacin for uncomplicated lower urinary tract infections. © The British Society for Antimicrobial Chemotherapy 2004; all rights reserved.
Filiaciones:
Instituto Nacional de Perinatología, Mexico City, Mexico
Unidad Apoyo a Investigacion Clin., Instituto Nacional de Pediatria, Mexico City, Mexico
Hospital General de Mexico, Mexico City, Mexico
Hospital Clínica del Parque, Chihuahua, Mexico
Hospital CIMA, Chihuahua, Mexico
Hospital Eugenio Espejo, Quito, Ecuador
Hospital del Sur, Quito, Ecuador
Hospital de Maternidad, San Salvador, El Salvador
Hospital Vargas de Caracas, Caracas, Venezuela
Fundación Lusara, Apartado Postal 102-006, 08930 Mexico City, Mexico
Bayer de México, Dirección Médica, Mexico City, Mexico
Quimica Farmaceutica Bayer, Barcelona, Spain
All Open Access, Bronze
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