HIV-1 inhibitory compounds from Calophyllum brasiliense leaves
Por:
Huerta-Reyes M., Basualdo M.D.C., Abe F., Jimenez-Estrada M., Soler C., Reyes-Chilpa R.
Publicada:
1 ene 2004
Resumen:
The hexane, acetone and methanol extracts of Calophyllum brasiliense leaves were fractionated following a three bioassay guide: high HIV-1 RT inhibition, low cytotoxicity on MT2 cells and high inhibition of HIV-1 IIIb/LAV replication. This led to the isolation of three anti HIV-1 dipyranocoumarins: calanolides A and B and soulattrolide. In contrast, other isolated compounds such as apetalic acid, isoapetalic acid, a structural isomer of isoapetalic acid, friedelin, canophyllol and amentoflavone were devoid of HIV-1 RT inhibitory activity. Calanolide C was also obtained as a natural product and showed moderate inhibitory properties. © 2004 Pharmaceutical Society of Japan.
Filiaciones:
Huerta-Reyes M.:
Department of Natural Products, Institute of Chemistry, National University of Mexico, 04510, Mexico D. F., Mexico
Basualdo M.D.C.:
HIV/AIDS Section, National University of Mexico, Ciudad Universitaria, 04510, Mexico D. F., Mexico
Abe F.:
Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan
Jimenez-Estrada M.:
Department of Natural Products, Institute of Chemistry, National University of Mexico, 04510, Mexico D. F., Mexico
Soler C.:
HIV/AIDS Section, National University of Mexico, Ciudad Universitaria, 04510, Mexico D. F., Mexico
Reyes-Chilpa R.:
Department of Natural Products, Institute of Chemistry, National University of Mexico, 04510, Mexico D. F., Mexico
All Open Access; Bronze
|