Epidermal growth factor and total protein in saliva of smokers and non smokers [Factor de crecimiento epidermal y proteínas totales en saliva de fumadores y no fumadores]
Por:
Gutiérrez Nova P., Olivares Navarrete R., Leyva Huerta E.R.
Publicada:
1 ene 2008
Resumen:
The role of Epidermal Growth Factor (EGF) is to maintain tissue's integrity. It's receptor is located on cell surfaces and mainly expressed in epithelia. The aim of this study was to determine the association between chronicle tabaquism, pH, total proteins (TP) and EGF in smoker's saliva. There were selected male volunteers between 20 and 60 years old from the Registration Clinic of the Postgrade Division of UNAM's Dentistry School. There were taken stimulated (sWHS) and not stimulated whole saliva (WHS) samples from groups of smoker's and non smokers. Total proteins (Bradford method), pH and EGF (ELISA Kit KHG0061 biosource) were measured. Results: Slightly alkaline pH in sWHS in both groups. TP were 1.11 ± 0.71 for non smokers WHS and 0.87 ± 0.31 mg/mL for smokers WHS. In non smokers WHS EGF were 14.8 ± 5.62 compared to smokers WHS which showed 11.4 ± 5.45. For sWHS the values were 7.8 ± 5.60 in non smokers group and 9.10 ± 6.53 ng/mL in smokers group.
Filiaciones:
Gutiérrez Nova P.:
Laboratorio de Patología Bucal, División de Estudios de Postgrado e Investigación, Universidad Nacional Autónoma de México, Circuito Institutos S/N, 04510 México, D.F., Mexico
Olivares Navarrete R.:
Laboratorio de Biología Celular y Molecular, División de Estudios de Postgrado e Investigación, Universidad Nacional Autónoma de México, Circuito Institutos S/N, 04510 México, D.F., Mexico
Leyva Huerta E.R.:
Laboratorio de Patología Clínica y Experimental, División de Estudios de Postgrado e Investigación, Universidad Nacional Autónoma de México, Circuito Institutos S/N, 04510 México, D.F., Mexico
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