Birth weight and blood lipid levels in Spanish adolescents: Influence of selected APOE, APOC3 and PPARgamma2 gene polymorphisms. The AVENA Study
Por:
Ruiz J.R., Labayen I., Ortega F.B., Moreno L.A., González-Lamuño D., Martí A., Nova E., Fuentes M.G., Redondo-Figuero C., Martínez J.A., Sjöström M., Castillo M.J., Cano M.D., Sola R., Mesa J.L., Delgado M., Tercedor P., Chillón P., Martín M., Carreño F., Rodríguez G.V., Castillo R., Arellano F., Marcos A., González-Gross M., Wärnberg J., Medina S., Sánchez Muniz F., Montero E., de la Rosa B., Gómez S., Samartín S., Romeo J., Álvarez R., Álvarez A., Barrios L., Leyva A., Payá B., Martínez L., Ramos E., Ortiz R., Urzanqui A., Zamora S., Garaulet M., Pérez-Llamas F., Baraza J.C., Marín J.F., Pérez de Heredia F., Fernández M.A., González C., García R., Torralba C., Donat E., Morales E., García M.D., Hernández J.J., Asensio A., Plaza F.J., López M.J., García Fuentes M., de Rufíno P., Pérez-Prieto R., Fernández D., Amigo T., Bueno M., Sarriá A., Fleta J., Rodríguez G., Gil C.M., Msana M.I., Casajús J.A., Blay V.Vicente, Blay M.G.
Publicada:
1 ene 2008
Resumen:
Background: There is increasing evidence indicating that genes involved in certain metabolic processes of cardiovascular diseases may be of particular influence in people with low body weight at birth. We examined whether the apolipoprotein (APO) E, APOC3 and the peroxisome proliferator-activated receptor-?-2 (PPAR?2) polymorphisms influence the association between low birth weight and blood lipid levels in healthy adolescents aged 13-18.5 years. Methods: A cross-sectional study of 502 Spanish adolescents born at term was conducted. Total (TC) and high density lipoprotein cholesterol (HDLc), triglycerides (TG), apolipoprotein (apo) A and B, and lipoprotein(a) [Lp(a)] were measured. Low density lipoprotein cholesterol (LDLc), TC-HDLc, TC/HDLc and apoB/apoA were calculated. Results: Low birth weight was associated with higher levels of TC, LDLc, apoB, Lp(a), TC-HDLc, TC/HDLc and apoB/apoA in males with the APOE ?3?4 genotype, whereas in females, it was associated with lower HDLc and higher TG levels. In males with the APOC3 S1/S2 genotype, low birth weight was associated with lower apoA and higher Lp(a), yet this association was not observed in females. There were no associations between low birth weight and blood lipids in any of the PPAR?2 genotypes. Conclusion: The results indicate that low birth weight has adeleterious influence on lipid profile particularly in adolescents with the APOE ?3/?4 genotype. These findings suggest that intrauterine environment interact with the genetic background affecting the lipid profile in later life. © 2008 Ruiz et al; licensee BioMed Central Ltd.
Filiaciones:
Ruiz J.R.:
Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain
Unit for Preventive Nutrition, Department of Biosciences and Nutrition at NOVUM, Karolinska Institutet, Huddinge, Sweden
Labayen I.:
Department of Nutrition and Food Science, University of the Basque Country, Vitoria, Spain
Ortega F.B.:
Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain
Unit for Preventive Nutrition, Department of Biosciences and Nutrition at NOVUM, Karolinska Institutet, Huddinge, Sweden
Moreno L.A.:
E. U. Ciencias de la Salud, University of Zaragoza, E-50009 Zaragoza, Spain
González-Lamuño D.:
Department of Pediatrics, University of Cantabria, 19003 Santander, Spain
Martí A.:
Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
Nova E.:
Immunonutrition Research Group, Department of Metabolism and Nutrition, Consejo Superior de Investigaciones Científicas, Madrid, Spain
Fuentes M.G.:
Department of Pediatrics, University of Cantabria, 19003 Santander, Spain
Redondo-Figuero C.:
Department of Pediatrics, University of Cantabria, 19003 Santander, Spain
Martínez J.A.:
Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
Sjöström M.:
Unit for Preventive Nutrition, Department of Biosciences and Nutrition at NOVUM, Karolinska Institutet, Huddinge, Sweden
Castillo M.J.:
Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain
Cano M.D.:
Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain
Sola R.:
Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain
Mesa J.L.:
Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain
Delgado M.:
Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain
Tercedor P.:
Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain
Chillón P.:
Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain
Martín M.:
Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain
Carreño F.:
Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain
Rodríguez G.V.:
Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain
Castillo R.:
Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain
Arellano F.:
Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain
Marcos A.:
Instituto de Nutrición y Bromatolgia, Consejo Superior de Investigaciones Científicas, E 28040 Madrid, Spain
González-Gross M.:
Instituto de Nutrición y Bromatolgia, Consejo Superior de Investigaciones Científicas, E 28040 Madrid, Spain
Wärnberg J.:
Instituto de Nutrición y Bromatolgia, Consejo Superior de Investigaciones Científicas, E 28040 Madrid, Spain
Medina S.:
Instituto de Nutrición y Bromatolgia, Consejo Superior de Investigaciones Científicas, E 28040 Madrid, Spain
Sánchez Muniz F.:
Instituto de Nutrición y Bromatolgia, Consejo Superior de Investigaciones Científicas, E 28040 Madrid, Spain
Montero E.:
Instituto de Nutrición y Bromatolgia, Consejo Superior de Investigaciones Científicas, E 28040 Madrid, Spain
de la Rosa B.:
Instituto de Nutrición y Bromatolgia, Consejo Superior de Investigaciones Científicas, E 28040 Madrid, Spain
Gómez S.:
Instituto de Nutrición y Bromatolgia, Consejo Superior de Investigaciones Científicas, E 28040 Madrid, Spain
Samartín S.:
Instituto de Nutrición y Bromatolgia, Consejo Superior de Investigaciones Científicas, E 28040 Madrid, Spain
Romeo J.:
Instituto de Nutrición y Bromatolgia, Consejo Superior de Investigaciones Científicas, E 28040 Madrid, Spain
Álvarez R.:
Instituto de Nutrición y Bromatolgia, Consejo Superior de Investigaciones Científicas, E 28040 Madrid, Spain
Álvarez A.:
Instituto de Nutrición y Bromatolgia, Consejo Superior de Investigaciones Científicas, E 28040 Madrid, Spain
Barrios L.:
Instituto de Nutrición y Bromatolgia, Consejo Superior de Investigaciones Científicas, E 28040 Madrid, Spain
Leyva A.:
Instituto de Nutrición y Bromatolgia, Consejo Superior de Investigaciones Científicas, E 28040 Madrid, Spain
Payá B.:
Instituto de Nutrición y Bromatolgia, Consejo Superior de Investigaciones Científicas, E 28040 Madrid, Spain
Martínez L.:
Instituto de Nutrición y Bromatolgia, Consejo Superior de Investigaciones Científicas, E 28040 Madrid, Spain
Ramos E.:
Instituto de Nutrición y Bromatolgia, Consejo Superior de Investigaciones Científicas, E 28040 Madrid, Spain
Ortiz R.:
Instituto de Nutrición y Bromatolgia, Consejo Superior de Investigaciones Científicas, E 28040 Madrid, Spain
Urzanqui A.:
Instituto de Nutrición y Bromatolgia, Consejo Superior de Investigaciones Científicas, E 28040 Madrid, Spain
Zamora S.:
Dpto. Fisiología, Universidad de Murcia, E 30100 Murcia, Spain
Garaulet M.:
Dpto. Fisiología, Universidad de Murcia, E 30100 Murcia, Spain
Pérez-Llamas F.:
Dpto. Fisiología, Universidad de Murcia, E 30100 Murcia, Spain
Baraza J.C.:
Dpto. Fisiología, Universidad de Murcia, E 30100 Murcia, Spain
Marín J.F.:
Dpto. Fisiología, Universidad de Murcia, E 30100 Murcia, Spain
Pérez de Heredia F.:
Dpto. Fisiología, Universidad de Murcia, E 30100 Murcia, Spain
Fernández M.A.:
Dpto. Fisiología, Universidad de Murcia, E 30100 Murcia, Spain
González C.:
Dpto. Fisiología, Universidad de Murcia, E 30100 Murcia, Spain
García R.:
Dpto. Fisiología, Universidad de Murcia, E 30100 Murcia, Spain
Torralba C.:
Dpto. Fisiología, Universidad de Murcia, E 30100 Murcia, Spain
Donat E.:
Dpto. Fisiología, Universidad de Murcia, E 30100 Murcia, Spain
Morales E.:
Dpto. Fisiología, Universidad de Murcia, E 30100 Murcia, Spain
García M.D.:
Dpto. Fisiología, Universidad de Murcia, E 30100 Murcia, Spain
Hernández J.J.:
Dpto. Fisiología, Universidad de Murcia, E 30100 Murcia, Spain
Asensio A.:
Dpto. Fisiología, Universidad de Murcia, E 30100 Murcia, Spain
Plaza F.J.:
Dpto. Fisiología, Universidad de Murcia, E 30100 Murcia, Spain
López M.J.:
Dpto. Fisiología, Universidad de Murcia, E 30100 Murcia, Spain
García Fuentes M.:
Department of Pediatrics, University of Cantabria, 19003 Santander, Spain
de Rufíno P.:
Department of Pediatrics, University of Cantabria, 19003 Santander, Spain
Pérez-Prieto R.:
Department of Pediatrics, University of Cantabria, 19003 Santander, Spain
Fernández D.:
Department of Pediatrics, University of Cantabria, 19003 Santander, Spain
Amigo T.:
Department of Pediatrics, University of Cantabria, 19003 Santander, Spain
Bueno M.:
E. U. Ciencias de la Salud, University of Zaragoza, E-50009 Zaragoza, Spain
Sarriá A.:
E. U. Ciencias de la Salud, University of Zaragoza, E-50009 Zaragoza, Spain
Fleta J.:
E. U. Ciencias de la Salud, University of Zaragoza, E-50009 Zaragoza, Spain
Rodríguez G.:
Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain
Gil C.M.:
E. U. Ciencias de la Salud, University of Zaragoza, E-50009 Zaragoza, Spain
Msana M.I.:
E. U. Ciencias de la Salud, University of Zaragoza, E-50009 Zaragoza, Spain
Casajús J.A.:
E. U. Ciencias de la Salud, University of Zaragoza, E-50009 Zaragoza, Spain
Blay V.Vicente:
E. U. Ciencias de la Salud, University of Zaragoza, E-50009 Zaragoza, Spain
Blay M.G.:
E. U. Ciencias de la Salud, University of Zaragoza, E-50009 Zaragoza, Spain
All Open Access, Gold
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