Ultrastructure of Dental Enamel afflicted with Hypoplasia: An Atomic Force Microscopic Study
Por:
Batina N., Renugopalakrishnan V., Casillas Lavin P.N., Guerrero J.C.H., Morales M., Garduño-Juárez R., Lakka S.L.
Publicada:
1 ene 2004
Resumen:
The ultrastructure of the human tooth enamel from a patient diagnosed with hypoplasia (HYP) was investigated using atomic force microscopy (AFM) and compared with the surface of normal human tooth enamel. Hypoplasia is a hereditary defect of dental enamel in which the enamel is deficient in either quality or quantity. AFM results presented for the HYP tooth enamel clearly demonstrate that the apatite crystal morphology in hypoplasia tooth enamel is perturbed in the diseased state which could result from a defective synthesis of the extracellular matrix proteins, e.g., amelogenin, by the ameloblasts. HYP enamel consisting of loosely packed, very small grains does not present a tendency for association, as in the case of the normal healthy tooth. Indeed, the enamel surface affected by HYP is porous and is made of much smaller grains. In some samples, the HYP part of enamel surface appeared in the form of a point-defect, which we believe may be associated with the early stages of the HYP deformation.
Filiaciones:
Batina N.:
Departamento de Química, Univ. Auton. Metropol.-Iztapalapa, 09340 México DF, Mexico
Renugopalakrishnan V.:
Children's Hospital, Harvard Medical School, Boston, MA 02115, United States
Department of Biomedical Engineering, Florida International University, Miami, FL 33174, United States
Casillas Lavin P.N.:
Facultad de Odontología, Univ. Nacional Autonoma de Mexico, 04510 México DF, Mexico
Guerrero J.C.H.:
Facultad de Odontología, Univ. Nacional Autonoma de Mexico, 04510 México DF, Mexico
Morales M.:
Departamento de Química, Univ. Auton. Metropol.-Iztapalapa, 09340 México DF, Mexico
Garduño-Juárez R.:
Centre de Ciencias Físicas, Univ. Nacional Autonoma de Mexico, 62210 Cuernavaca, Morelos, Mexico
Lakka S.L.:
Department of Biomedical Engineering, Florida International University, Miami, FL 33174, United States
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